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TP0586532, a non-hydroxamate LpxC inhibitor, reduces LPS release and IL-6 production both in vitro and in vivo.
Fujita, Kiyoko; Takata, Iichiro; Yoshida, Ippei; Takashima, Hajime; Sugiyama, Hiroyuki.
Affiliation
  • Fujita K; Pharmacology Laboratotries, Taisho Pharmaceutical Co., Ltd, Saitama, Japan.
  • Takata I; Pharmacology Laboratotries, Taisho Pharmaceutical Co., Ltd, Saitama, Japan.
  • Yoshida I; Pharmacology Laboratotries, Taisho Pharmaceutical Co., Ltd, Saitama, Japan.
  • Takashima H; Chemistry Laboratories, Taisho Pharmaceutical Co., Ltd, Saitama, Japan.
  • Sugiyama H; Pharmacology Laboratotries, Taisho Pharmaceutical Co., Ltd, Saitama, Japan. hiro-sugiyama@taisho.co.jp.
J Antibiot (Tokyo) ; 75(3): 136-145, 2022 03.
Article in En | MEDLINE | ID: mdl-34987187
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lipopolysaccharides / Interleukin-6 / Enzyme Inhibitors / Amidohydrolases / Hydroxamic Acids / Anti-Bacterial Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Antibiot (Tokyo) Year: 2022 Document type: Article Affiliation country: Japan Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lipopolysaccharides / Interleukin-6 / Enzyme Inhibitors / Amidohydrolases / Hydroxamic Acids / Anti-Bacterial Agents Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Antibiot (Tokyo) Year: 2022 Document type: Article Affiliation country: Japan Country of publication: United kingdom