The control of experimental allergic encephalomyelitis with retinoic acid. Further studies.
Riv Neurol
; 57(3): 166-9, 1987.
Article
in En
| MEDLINE
| ID: mdl-3499654
ABSTRACT
Two form of retinoic acid (RA) prevented the development of experimental allergic encephalomyelitis (EAE) in Lewis rats. RA suspended in corn oil was given before the expected onset of the disease to rats immunized with myelin and to controls. The drug suppressed the neurological symptoms as well as the perivascular infiltrates observed in vehicle treated animals. The results indicate that, under these experimental conditions, RA has immunosuppressive activity by interfering with the efferent phase of the immune response.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tretinoin
/
Encephalomyelitis, Autoimmune, Experimental
Limits:
Animals
Language:
En
Journal:
Riv Neurol
Year:
1987
Document type:
Article