The Role of Na+/K+-ATPase in the Development of Hyponatrenemia under Conditions of Hypoxic Stress in Patients with SARS-CoV-2 Infection.
Bull Exp Biol Med
; 172(3): 283-287, 2022 Jan.
Article
in En
| MEDLINE
| ID: mdl-34997875
ABSTRACT
We studied laboratory parameters of patients with COVID-19 against the background of chronic pathologies (cardiovascular pathologies, obesity, type 2 diabetes melitus, and cardiovascular pathologies with allergy to statins). A decrease in pH and a shift in the electrolyte balance of blood plasma were revealed in all studied groups and were most pronounced in patients with cardiovascular pathologies with allergy to statin. It was found that low pH promotes destruction of lipid components of the erythrocyte membranes in patients with chronic pathologies, which was seen from a decrease in Na+/K+-ATPase activity and significant hyponatrenemia. In patients with cardiovascular pathologies and allergy to statins, erythrocyte membranes were most sensitive to a decrease in pH, while erythrocyte membranes of obese patients showed the greatest resistance to low pH and oxidative stress.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sodium-Potassium-Exchanging ATPase
/
COVID-19
/
Hyponatremia
/
Hypoxia
Type of study:
Observational_studies
/
Risk_factors_studies
Language:
En
Journal:
Bull Exp Biol Med
Year:
2022
Document type:
Article
Affiliation country:
Azerbaijan