nCP:Fe Nanocontrast Agent for Magnetic Resonance Imaging-Based Early Detection of Liver Cirrhosis and Hepatocellular Carcinoma.
ACS Appl Bio Mater
; 4(4): 3398-3409, 2021 04 19.
Article
in En
| MEDLINE
| ID: mdl-35014424
ABSTRACT
Early detection of liver tumors and cirrhotic lesions by magnetic resonance imaging (MRI) remains a great challenge. Here, we report a biomineral nanocontrast agent based on iron-doped nanocalcium phosphate (nCPFe-CA) for magnetic resonance imaging of early-stage liver cirrhotic and hepatocellular carcinoma nodules using rat models. We have optimized an intravenously injectable, aqueous suspension of nCPFe-CA having an average size of 137.6 nm, a spherical shape, magnetic relaxivity of 63 mM-1S-1, and colloidal stability for 48 h, post-resuspension in an aqueous phase. Compared to superparamagnetic iron oxide nanoparticles (SPIONs), the optimized nCPFe-CA could detect liver tumor lesions as small as â¼0.25 cm, whereas the current clinical detection limit is â¼1 cm. In addition, multiple cirrhotic nodules of size <0.2 cm could be detected by nCPFe-CA-assisted MRI. The number of nodules observed after injecting nCPFe-CA was â¼3 times higher than that without CA (5-10 nodules). A biocompatibility study on healthy rats injected with nCPFe-CA showed unaltered liver transaminases, blood urea nitrogen, serum creatinine, and insignificant hemolysis. Furthermore, hepatobiliary clearance of nCPFe-CA was observed in 72 h compared to prolonged retention of SPIONs for 30 days when tested under identical conditions. Overall, the nCPFe-CA nanoparticles showed promising results as a biocompatible, MR contrast (T2) agent for the early-stage imaging of liver cirrhosis and hepatocellular carcinoma.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biocompatible Materials
/
Calcium Phosphates
/
Magnetic Resonance Imaging
/
Carcinoma, Hepatocellular
/
Iron
/
Liver Cirrhosis
/
Liver Neoplasms
Type of study:
Diagnostic_studies
/
Screening_studies
Limits:
Animals
Language:
En
Journal:
ACS Appl Bio Mater
Year:
2021
Document type:
Article
Affiliation country:
India