CDK4 and CDK6 kinases: From basic science to cancer therapy.

Fassl, Anne; Geng, Yan; Sicinski, Piotr

Fassl, Anne; Geng, Yan; Sicinski, Piotr.

Affiliation

Fassl A; Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02215, USA.
Geng Y; Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02215, USA.
Sicinski P; Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02215, USA.

Science ; 375(6577): eabc1495, 2022 Jan 14.

Article in En | MEDLINE | ID: mdl-35025636

Subject(s)

Cyclin-Dependent Kinase 4/antagonists & inhibitors; Cyclin-Dependent Kinase 4/metabolism; Cyclin-Dependent Kinase 6/antagonists & inhibitors; Cyclin-Dependent Kinase 6/metabolism; Neoplasms/drug therapy; Animals; Antineoplastic Agents/adverse effects; Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Antineoplastic Combined Chemotherapy Protocols/pharmacology; Antineoplastic Combined Chemotherapy Protocols/therapeutic use; Carcinogenesis; Cell Proliferation/drug effects; Cellular Senescence; Clinical Trials as Topic; Drug Resistance, Neoplasm; Drug Synergism; Humans; Neoplasms/immunology; Neoplasms/metabolism; Neoplasms/pathology; Protein Kinase Inhibitors/pharmacology; Protein Kinase Inhibitors/therapeutic use

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cyclin-Dependent Kinase 4 / Cyclin-Dependent Kinase 6 / Neoplasms Limits: Animals / Humans Language: En Journal: Science Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google