Your browser doesn't support javascript.
loading
Multi-omic analysis in injured humans: Patterns align with outcomes and treatment responses.
Wu, Junru; Vodovotz, Yoram; Abdelhamid, Sultan; Guyette, Francis X; Yaffe, Michael B; Gruen, Danielle S; Cyr, Anthony; Okonkwo, David O; Kar, Upendra K; Krishnamoorthi, Neha; Voinchet, Robert G; Billiar, Isabel M; Yazer, Mark H; Namas, Rami A; Daley, Brian J; Miller, Richard S; Harbrecht, Brian G; Claridge, Jeffrey A; Phelan, Herbert A; Zuckerbraun, Brian S; Johansson, Pär I; Stensballe, Jakob; Morrissey, James H; Tracy, Russell P; Wisniewski, Stephen R; Neal, Matthew D; Sperry, Jason L; Billiar, Timothy R.
Affiliation
  • Wu J; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  • Vodovotz Y; Pittsburgh Trauma Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
  • Abdelhamid S; Department of Cardiology & Center of Pharmacology, The 3rd Xiangya Hospital, Central South University, Changsha, China.
  • Guyette FX; Eight-Year Program of Medicine, Xiangya School of Medicine, Central South University, Changsha, China.
  • Yaffe MB; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  • Gruen DS; Pittsburgh Trauma Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
  • Cyr A; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  • Okonkwo DO; Pittsburgh Trauma Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
  • Kar UK; Department of Emergency Medicine, Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Krishnamoorthi N; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Voinchet RG; Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Billiar IM; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  • Yazer MH; Pittsburgh Trauma Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
  • Namas RA; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  • Daley BJ; Pittsburgh Trauma Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
  • Miller RS; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  • Harbrecht BG; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  • Claridge JA; Pittsburgh Trauma Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
  • Phelan HA; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  • Zuckerbraun BS; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  • Johansson PI; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  • Stensballe J; The Institute for Transfusion Medicine, Pittsburgh, PA, USA.
  • Morrissey JH; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
  • Tracy RP; Pittsburgh Trauma Research Center, University of Pittsburgh, Pittsburgh, PA, USA.
  • Wisniewski SR; Department of Surgery, University of Tennessee Health Science Center, Knoxville, TN, USA.
  • Neal MD; Department of Surgery, JPS Health Network in Fort Worth, TX, USA.
  • Sperry JL; Department of Surgery, University of Louisville, Louisville, KY, USA.
  • Billiar TR; Metro Health Medical Center, Case Western Reserve University, Cleveland, OH, USA.
Cell Rep Med ; 2(12): 100478, 2021 12 21.
Article in En | MEDLINE | ID: mdl-35028617
ABSTRACT
Trauma is a leading cause of death and morbidity worldwide. Here, we present the analysis of a longitudinal multi-omic dataset comprising clinical, cytokine, endotheliopathy biomarker, lipidome, metabolome, and proteome data from severely injured humans. A "systemic storm" pattern with release of 1,061 markers, together with a pattern suggestive of the "massive consumption" of 892 constitutive circulating markers, is identified in the acute phase post-trauma. Data integration reveals two human injury response endotypes, which align with clinical trajectory. Prehospital thawed plasma rescues only endotype 2 patients with traumatic brain injury (30-day mortality 30.3 versus 75.0%; p = 0.0015). Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) was identified as the most predictive circulating biomarker to identify endotype 2-traumatic brain injury (TBI) patients. These response patterns refine the paradigm for human injury, while the datasets provide a resource for the study of critical illness, trauma, and human stress responses.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genomics / Brain Injuries, Traumatic Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Cell Rep Med Year: 2021 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genomics / Brain Injuries, Traumatic Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: En Journal: Cell Rep Med Year: 2021 Document type: Article Affiliation country: United States