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Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice.
Matsuda, Hiroki; Nibe-Shirakihara, Yoichi; Tamura, Akiko; Aonuma, Emi; Arakawa, Satoko; Otsubo, Kana; Nemoto, Yasuhiro; Nagaishi, Takashi; Tsuchiya, Kiichiro; Shimizu, Shigeomi; Ma, Averil; Watanabe, Mamoru; Uo, Motohiro; Okamoto, Ryuichi; Oshima, Shigeru.
Affiliation
  • Matsuda H; Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
  • Nibe-Shirakihara Y; Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Japan.
  • Tamura A; Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
  • Aonuma E; Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
  • Arakawa S; Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Japan.
  • Otsubo K; Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
  • Nemoto Y; Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
  • Nagaishi T; Department of Advanced Therapeutics for G.I. Diseases, Tokyo Medical and Dental University, Tokyo, Japan.
  • Tsuchiya K; Department of Gastroenterology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Shimizu S; Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Japan.
  • Ma A; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Watanabe M; Advanced Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
  • Uo M; Department of Advanced Biomaterials, Tokyo Medical and Dental University, Tokyo, Japan.
  • Okamoto R; Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.
  • Oshima S; Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address: soshima.gast@tmd.ac.jp.
Biochem Biophys Res Commun ; 592: 74-80, 2022 02 12.
Article in En | MEDLINE | ID: mdl-35032835
ABSTRACT
Crohn's disease is an inflammatory disease of the gut caused by a complex interplay among genetic, microbial, and environmental factors. The intestinal tract is constantly exposed to metals and other trace elements ingested as food. Synchrotron radiation-induced X-ray fluorescence spectroscopy and X-ray absorption fine structure analysis revealed the deposition of nickel particles within Crohn's disease tissue specimens. After nickel particle stimulation, THP-1 cells showed filopodia formation and autophagic vacuoles containing lipid bodies. Nickel particles precipitated colitis in mice bearing mutations of the IBD susceptibility protein A20/TNFAIP3. Nickel particles also exacerbated dextran sulfate sodium-induced colitis in mice harboring myeloid cell-specific Atg5 deficiency. These findings illustrate that nickel particle ingestion may worsen Crohn's disease by perturbing autophagic processes in the intestine, providing new insights into environmental factors in Crohn's disease pathogenesis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crohn Disease / Disease Progression / Inflammation / Intestines / Nickel Limits: Animals / Humans Language: En Journal: Biochem Biophys Res Commun Year: 2022 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Crohn Disease / Disease Progression / Inflammation / Intestines / Nickel Limits: Animals / Humans Language: En Journal: Biochem Biophys Res Commun Year: 2022 Document type: Article Affiliation country: Japan