18F-fluorocholine PET/CT and conventional imaging in primary hyperparathyroidism.
Diagn Interv Imaging
; 103(5): 258-265, 2022 May.
Article
in En
| MEDLINE
| ID: mdl-35039246
ABSTRACT
PURPOSE:
The purpose of this study was to assess the diagnostic capabilities of preoperative conventional imaging (99mTc-MIBI scintigraphy, cervical ultrasonography [CUS]) and 18F-fluorocholine PET/CT (FCH PET/CT) in the detection of hyperfunctioning parathyroid gland in patients with primary hyperparathyroidism (PHPT) used alone or as a single imaging set. MATERIALS ANDMETHODS:
A total of 51 consecutive patients (6 men, 45 women; mean age, 62 ± 11.6 [SD] years; age range 28-86 years) with biochemically confirmed PHPT who underwent CUS, single-tracer dual phase 99mTc-MIBI scintigraphy and FCH PET/CT were retrospectively included. 99mTc-MIBI scintigraphy were performed immediately after CUS and interpreted by the same operators. FCH PET/CT examinations were interpreted independently by two nuclear medicine physicians. An additional reading session integrating the three imaging modalities read in consensus as a combined imaging set was performed.RESULTS:
At surgery, 74 lesions were removed (32 parathyroid adenomas, 38 parathyroid hyperplasia and 4 subnormal glands). Thirty-six patients (71%) had single-gland disease and 15 patients (29%) had multiglandular disease at histopathological analysis. On a patient basis, sensitivity and accuracy of FCH PET/CT, CUS and 99mTc-MIBI scintigraphy for the detection of abnormal parathyroid glands were 76% (95% CI 63-87%) and 76% (95% CI 63-87%), 71% (95% CI 56-83%) and 71% (95% CI 56-83%), 33% (95% CI 21-48%) and 33% (95% CI 21-48%), respectively. The sensitivity of the combined imaging set was 94% (95% CI 84-99%) and greater than the sensitivity of each individual imaging technique (P ≤ 0.001 for all).CONCLUSION:
Our results suggest that CUS, 99mTc-MIBI scintigraphy and FCH PET/CT interpreted as a single imaging set could be the ideal practice to precisely localize parathyroid lesion in patients with PHPT before surgery.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hyperparathyroidism, Primary
/
Positron Emission Tomography Computed Tomography
Type of study:
Observational_studies
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Diagn Interv Imaging
Year:
2022
Document type:
Article
Publication country:
FR
/
FRANCE
/
FRANCIA
/
FRANÇA