F,N-Doped carbon dots as efficient Type I photosensitizers for photodynamic therapy.
Dalton Trans
; 51(6): 2296-2303, 2022 Feb 08.
Article
in En
| MEDLINE
| ID: mdl-35040834
ABSTRACT
Photodynamic therapy (PDT) is a promising and emerging method for the treatment of cancer. Usually, Type II PDT is used in the clinic, and mainly involves three key elements a photosensitizer, molecular oxygen and laser light. However, it is known that tumor tissue is deficient in oxygen molecules which is why Type I PDT is mostly preferred in the therapy of tumors in which the hypoxic tissue plays a major role. Fluorescent carbon dots (CDs) have shown great potential in cancer theranostics, acting as bioimaging agents and photosensitizers. Herein, we have synthesized novel kinds of fluorine and nitrogen co-doped carbon dots (F,NCDs) that emit bright green fluorescence under ultra-violet light. The F,NCDs have excellent water solubility and low cytotoxicity. They can generate hydroxyl radicals (ËOH) and superoxide anions (ËO2-) under LED light (400-500 nm, 15 mW cm-2) irradiation, making them ideal photosensitizers for Type I PDT. Furthermore, upon using the HepG2 cell line as an in vitro model, the F,NCDs exhibit a better cell imaging effect and higher PDT efficiency than the control sample of CDs without F and N doping. This work has illustrated that the F,NCDs are promising in achieving the image-guided PDT of cancers, usually in a hypoxia tumor microenvironment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Photosensitizing Agents
Language:
En
Journal:
Dalton Trans
Journal subject:
QUIMICA
Year:
2022
Document type:
Article
Affiliation country:
China