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An Integrated Strategy for Assessing the Metabolic Stability and Biotransformation of Macrocyclic Peptides in Drug Discovery toward Oral Delivery.
Guo, Yukuang; Ji, Shaofei; Wang, Wei; Wong, Susan; Yen, Chun-Wan; Hu, Chloe; Leung, Dennis H; Plise, Emile; Zhang, Shu; Zhang, Chenghong; Anene, Uchenna A; Zhang, Donglu; Cunningham, Christian N; Khojasteh, S Cyrus; Su, Dian.
Affiliation
  • Guo Y; Genentech, 1 DNA Way, South San Francisco, California 94080, United States.
  • Ji S; Genentech, 1 DNA Way, South San Francisco, California 94080, United States.
  • Wang W; Genentech, 1 DNA Way, South San Francisco, California 94080, United States.
  • Wong S; Genentech, 1 DNA Way, South San Francisco, California 94080, United States.
  • Yen CW; Genentech, 1 DNA Way, South San Francisco, California 94080, United States.
  • Hu C; Genentech, 1 DNA Way, South San Francisco, California 94080, United States.
  • Leung DH; Genentech, 1 DNA Way, South San Francisco, California 94080, United States.
  • Plise E; Genentech, 1 DNA Way, South San Francisco, California 94080, United States.
  • Zhang S; Genentech, 1 DNA Way, South San Francisco, California 94080, United States.
  • Zhang C; Genentech, 1 DNA Way, South San Francisco, California 94080, United States.
  • Anene UA; Genentech, 1 DNA Way, South San Francisco, California 94080, United States.
  • Zhang D; Genentech, 1 DNA Way, South San Francisco, California 94080, United States.
  • Cunningham CN; Genentech, 1 DNA Way, South San Francisco, California 94080, United States.
  • Khojasteh SC; Genentech, 1 DNA Way, South San Francisco, California 94080, United States.
  • Su D; Genentech, 1 DNA Way, South San Francisco, California 94080, United States.
Anal Chem ; 94(4): 2032-2041, 2022 02 01.
Article in En | MEDLINE | ID: mdl-35041378
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Hydrolases / Peptides Limits: Humans Language: En Journal: Anal Chem Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Hydrolases / Peptides Limits: Humans Language: En Journal: Anal Chem Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States