Molecular Characterization of Mycobacterium ulcerans DNA Gyrase and Identification of Mutations Reducing Susceptibility to Quinolones <i>In Vitro</i>.

Kim, Hyun; Mori, Shigetarou; Kenri, Tsuyoshi; Suzuki, Yasuhiko

Molecular Characterization of Mycobacterium ulcerans DNA Gyrase and Identification of Mutations Reducing Susceptibility to Quinolones In Vitro.

Kim, Hyun; Mori, Shigetarou; Kenri, Tsuyoshi; Suzuki, Yasuhiko.

Affiliation

Kim H; Department of Bacteriology II, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.
Mori S; Department of Bacteriology II, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.
Kenri T; Department of Bacteriology II, National Institute of Infectious Diseasesgrid.410795.e, Tokyo, Japan.
Suzuki Y; Division of Bioresources, Hokkaido Universitygrid.39158.36 International Institute for Zoonosis Control, Sapporo, Japan.

Antimicrob Agents Chemother ; 66(4): e0190221, 2022 04 19.

Article in En | MEDLINE | ID: mdl-35041504

Subject(s)

Mycobacterium ulcerans; Quinolones; DNA Gyrase/metabolism; Drug Resistance, Bacterial/genetics; Fluoroquinolones/pharmacology; Microbial Sensitivity Tests; Molecular Docking Simulation; Mutation; Mycobacterium ulcerans/genetics; Quinolones/pharmacology

Key words

Buruli ulcer disease; DNA gyrase; Mycobacterium ulcerans; fluoroquinolone resistance; molecular docking study; supercoiling assay

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolones / Mycobacterium ulcerans Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: Antimicrob Agents Chemother Year: 2022 Document type: Article Affiliation country: Japan Country of publication: United States

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