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A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs.
Liu, Zezhong; Zhou, Jie; Xu, Wei; Deng, Wei; Wang, Yanqun; Wang, Meiyu; Wang, Qian; Hsieh, Ming; Dong, Jingming; Wang, Xinling; Huang, Weijin; Xing, Lixiao; He, Miaoling; Tao, Chunlin; Xie, Youhua; Zhang, Yilong; Wang, Youchun; Zhao, Jincun; Yuan, Zhenghong; Qin, Chuan; Jiang, Shibo; Lu, Lu.
Affiliation
  • Liu Z; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences; Shanghai Institute of Infectious Disease and Biosecurity; Biosafety Level 3 Laboratory, Shanghai Medical College, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Fudan University, S
  • Zhou J; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences; Shanghai Institute of Infectious Disease and Biosecurity; Biosafety Level 3 Laboratory, Shanghai Medical College, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Fudan University, S
  • Xu W; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences; Shanghai Institute of Infectious Disease and Biosecurity; Biosafety Level 3 Laboratory, Shanghai Medical College, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Fudan University, S
  • Deng W; Key Laboratory of Human Disease Comparative Medicine, National Health Commission of the People's Republic of China; Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Comparative Med
  • Wang Y; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Wang M; Institute of Infectious Disease, Guangzhou Eighth People's Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
  • Wang Q; Guangzhou Laboratory, Bio-Island, Guangzhou, China.
  • Hsieh M; Graduate School of Peking Union Medical College, No. 9 Dongdan Santiao, Dongcheng District, Beijing, China.
  • Dong J; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), No. 31 Huatuo Street, Daxing District, Beijing, China.
  • Wang X; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences; Shanghai Institute of Infectious Disease and Biosecurity; Biosafety Level 3 Laboratory, Shanghai Medical College, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Fudan University, S
  • Huang W; Fulgent Pharma LLC., 4978 Santa Anita Avenue, Temple City, CA, USA.
  • Xing L; Fulgent Pharma LLC., 4978 Santa Anita Avenue, Temple City, CA, USA.
  • He M; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences; Shanghai Institute of Infectious Disease and Biosecurity; Biosafety Level 3 Laboratory, Shanghai Medical College, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Fudan University, S
  • Tao C; Graduate School of Peking Union Medical College, No. 9 Dongdan Santiao, Dongcheng District, Beijing, China.
  • Xie Y; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), No. 31 Huatuo Street, Daxing District, Beijing, China.
  • Zhang Y; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences; Shanghai Institute of Infectious Disease and Biosecurity; Biosafety Level 3 Laboratory, Shanghai Medical College, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Fudan University, S
  • Wang Y; Fulgent Pharma LLC., 4978 Santa Anita Avenue, Temple City, CA, USA.
  • Zhao J; Fulgent Pharma LLC., 4978 Santa Anita Avenue, Temple City, CA, USA.
  • Yuan Z; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences; Shanghai Institute of Infectious Disease and Biosecurity; Biosafety Level 3 Laboratory, Shanghai Medical College, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Fudan University, S
  • Qin C; Fulgent Pharma LLC., 4978 Santa Anita Avenue, Temple City, CA, USA. yilongzhang@fulgentpharma.com.
  • Jiang S; Graduate School of Peking Union Medical College, No. 9 Dongdan Santiao, Dongcheng District, Beijing, China. wangyc@nifdc.org.cn.
  • Lu L; Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control (NIFDC), No. 31 Huatuo Street, Daxing District, Beijing, China. wangyc@nifdc.org.cn.
Cell Res ; 32(3): 269-287, 2022 03.
Article in En | MEDLINE | ID: mdl-35046518
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vaccines / COVID-19 Limits: Animals Language: En Journal: Cell Res Year: 2022 Document type: Article Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vaccines / COVID-19 Limits: Animals Language: En Journal: Cell Res Year: 2022 Document type: Article Country of publication: United kingdom