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Effector memory CD4+ T cells induce damaging innate inflammation and autoimmune pathology by engaging CD40 and TNFR on myeloid cells.
McDaniel, Margaret M; Chawla, Amanpreet Singh; Jain, Aakanksha; Meibers, Hannah E; Saha, Irene; Gao, Yajing; Jain, Viral; Roskin, Krishna; Way, Sing Sing; Pasare, Chandrashekhar.
Affiliation
  • McDaniel MM; Immunology Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Chawla AS; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
  • Jain A; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
  • Meibers HE; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
  • Saha I; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
  • Gao Y; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
  • Jain V; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
  • Roskin K; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
  • Way SS; Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
  • Pasare C; Immunology Graduate Program, Cincinnati Children's Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45220, USA.
Sci Immunol ; 7(67): eabk0182, 2022 01 21.
Article in En | MEDLINE | ID: mdl-35061504
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / CD4-Positive T-Lymphocytes / Receptors, Tumor Necrosis Factor / CD40 Antigens / Myeloid Cells / Inflammation Type of study: Prognostic_studies Limits: Animals Language: En Journal: Sci Immunol Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoimmune Diseases / CD4-Positive T-Lymphocytes / Receptors, Tumor Necrosis Factor / CD40 Antigens / Myeloid Cells / Inflammation Type of study: Prognostic_studies Limits: Animals Language: En Journal: Sci Immunol Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States