Ribosomal DNA and the nucleolus at the heart of aging.
Trends Biochem Sci
; 47(4): 328-341, 2022 04.
Article
in En
| MEDLINE
| ID: mdl-35063340
ABSTRACT
The rRNA genes [ribosomal DNA (rDNA)] are organized in a prominent nuclear compartment, the nucleolus. It is now well established that the nucleolus functions beyond ribosome biosynthesis, regulating several physiological cellular responses. The nucleoli constitute dynamic genomic/nuclear hubs and demonstrate unique inherent characteristics, rendering them ideal to sense, signal, and respond to various intrinsic and environmental insults. Here, we discuss emerging findings supporting direct links between rDNA/nucleolar instability and cellular senescence/organismal aging from yeast to mammals. Moreover, we highlight evidence that nucleolar functionality and rDNA architecture impact on meiotic/transgenerational rejuvenation, thus revealing causality underlying connections between rDNA/nucleolar instability and aging.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aging
/
Cell Nucleolus
Limits:
Animals
Language:
En
Journal:
Trends Biochem Sci
Year:
2022
Document type:
Article
Affiliation country:
Greece