Diaryl triazenes inhibit cytochrome P450 1A1 and 1B1 more strongly than aryl morpholino triazenes.

Moran, Rachel; Nakamura, Ryan; Isovitsch, Ralph; Iimoto, Devin

Moran, Rachel; Nakamura, Ryan; Isovitsch, Ralph; Iimoto, Devin.

Affiliation

Moran R; Department of Chemistry, Whittier College, Whittier, CA 90608, United States. Electronic address: rachelmoran01@gmail.com.
Nakamura R; Department of Chemistry, Whittier College, Whittier, CA 90608, United States. Electronic address: rnakamura@pcareplus.com.
Isovitsch R; Department of Chemistry, Whittier College, Whittier, CA 90608, United States. Electronic address: risovitsch@whittier.edu.
Iimoto D; Department of Chemistry, Whittier College, Whittier, CA 90608, United States. Electronic address: diimoto@whittier.edu.

Bioorg Med Chem Lett ; 59: 128570, 2022 03 01.

Article in En | MEDLINE | ID: mdl-35063631

Subject(s)

Cytochrome P-450 CYP1A1/antagonists & inhibitors; Cytochrome P-450 CYP1B1/antagonists & inhibitors; Cytochrome P-450 Enzyme Inhibitors/pharmacology; Morpholinos/pharmacology; Triazenes/pharmacology; Cytochrome P-450 CYP1A1/metabolism; Cytochrome P-450 CYP1B1/metabolism; Cytochrome P-450 Enzyme Inhibitors/chemical synthesis; Cytochrome P-450 Enzyme Inhibitors/chemistry; Dose-Response Relationship, Drug; Humans; Molecular Structure; Morpholinos/chemical synthesis; Morpholinos/chemistry; Structure-Activity Relationship; Triazenes/chemical synthesis; Triazenes/chemistry

Key words

Cancer; Cytochrome P450 1A1; Cytochrome P450 1B1; Inhibition; Synthesis; Triazenes

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triazenes / Cytochrome P-450 CYP1A1 / Morpholinos / Cytochrome P-450 CYP1B1 / Cytochrome P-450 Enzyme Inhibitors Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2022 Document type: Article Country of publication: United kingdom

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