Synthesis of Hemiprotonic Phenanthroline-Phenanthroline<sup>+</sup> Compounds with both Antitumor and Antimicrobial Activity.

Zhao, Zizhen; Li, Xiaorong; Cui, Zhihong; Tong, Tingting; Zhang, Yingying; Zhang, Yuping; Yang, Xiaoxi; Keerthiga, Rajendiran; Fu, Chen; Fu, Ailing

Synthesis of Hemiprotonic Phenanthroline-Phenanthroline⁺ Compounds with both Antitumor and Antimicrobial Activity.

Zhao, Zizhen; Li, Xiaorong; Cui, Zhihong; Tong, Tingting; Zhang, Yingying; Zhang, Yuping; Yang, Xiaoxi; Keerthiga, Rajendiran; Fu, Chen; Fu, Ailing.

Affiliation

Zhao Z; College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Li X; College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Cui Z; College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Tong T; College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Zhang Y; College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Zhang Y; College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Yang X; College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Keerthiga R; College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Fu C; College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Fu A; College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.

J Med Chem ; 65(3): 2532-2547, 2022 02 10.

Article in En | MEDLINE | ID: mdl-35073076

Subject(s)

Anti-Infective Agents/therapeutic use; Antineoplastic Agents/therapeutic use; Encephalitis/drug therapy; Neoplasms/drug therapy; Phenanthrolines/therapeutic use; Pneumonia/drug therapy; Animals; Anti-Bacterial Agents/chemical synthesis; Anti-Bacterial Agents/pharmacology; Anti-Bacterial Agents/therapeutic use; Anti-Bacterial Agents/toxicity; Anti-Infective Agents/chemical synthesis; Anti-Infective Agents/pharmacology; Anti-Infective Agents/toxicity; Antifungal Agents/chemical synthesis; Antifungal Agents/pharmacology; Antifungal Agents/therapeutic use; Antifungal Agents/toxicity; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/pharmacology; Antineoplastic Agents/toxicity; Apoptosis/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Cryptococcus neoformans/drug effects; DNA-Binding Proteins/metabolism; Encephalitis/complications; Humans; Male; Methicillin-Resistant Staphylococcus aureus/drug effects; Mice, Inbred C57BL; Microbial Sensitivity Tests; Neoplasms/complications; Phenanthrolines/chemical synthesis; Phenanthrolines/pharmacology; Phenanthrolines/toxicity; Pneumonia/complications; Protons; RNA-Binding Proteins/metabolism; Transcription Factors/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenanthrolines / Pneumonia / Encephalitis / Anti-Infective Agents / Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: China

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