Pinus thunbergii bark extract rich in flavonoids promotes hair growth in dorsal skin by regulating inflammatory cytokines and increasing growth factors in mice.
Mol Med Rep
; 25(3)2022 03.
Article
in En
| MEDLINE
| ID: mdl-35088884
ABSTRACT
Korean maritime pine bark (Pinus thunbergii) has been used as an alternative medicine due to its beneficial properties, including antiinflammatory effects. To date, the antiinflammatory and hair growthpromoting effects of Pinus densiflora bark extract have remained elusive. Therefore, in the present study, Pinus thunbergii bark was extracted with pure water (100ËC) and the extract was examined to determine its polyphenol and flavonoid content. C57BL/6 mice were used to assess the effects of the extract to promote hair growth. The extract (1, 2 and 4%) was topically applied onto shaved dorsal skin and hair growth was observed for 17 days. A significant increase in hair growth was observed with 2 and 4% extract. Based on this finding, the optimal dose of the extract for effective hair growth promotion was determined to be 2%. The mechanisms of hair growth promotion were investigated via immunohistochemical analysis of changes in inflammatory cytokines and growth factors in the hair follicles following treatment with 2% extract. The treatment reduced the levels of TNFα and IL1ß, which are proinflammatory cytokines, while it enhanced the levels of IL4 and IL13, which are antiinflammatory cytokines, in the hair follicles. In addition, elevated insulinlike growth factor I and vascular epidermal growth factor were detected in hair follicles following treatment. Based on these findings, it was suggested that the extract of Pinus thunbergii bark may be utilized for hair loss prevention and/or hair growth promotion.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pinus
Limits:
Animals
Language:
En
Journal:
Mol Med Rep
Year:
2022
Document type:
Article
Publication country:
GR
/
GRECIA
/
GREECE
/
GRÉCIA