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TdfH selectively binds metal-loaded tetrameric calprotectin for zinc import.
Bera, Aloke K; Wu, Runrun; Harrison, Simone; Cornelissen, Cynthia Nau; Chazin, Walter J; Noinaj, Nicholas.
Affiliation
  • Bera AK; Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA.
  • Wu R; Interdisciplinary Life Science - PULSe, Purdue University, West Lafayette, IN, 47907, USA.
  • Harrison S; Departments of Biochemistry and Chemistry, and Center for Structural Biology, Vanderbilt University, Nashville, TN, 37240, USA.
  • Cornelissen CN; Center for Translational Immunology, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, 30303, USA.
  • Chazin WJ; Departments of Biochemistry and Chemistry, and Center for Structural Biology, Vanderbilt University, Nashville, TN, 37240, USA.
  • Noinaj N; Department of Biological Sciences, Purdue University, West Lafayette, IN, 47907, USA. nnoinaj@purdue.edu.
Commun Biol ; 5(1): 103, 2022 01 31.
Article in En | MEDLINE | ID: mdl-35102276
ABSTRACT
To combat nutritional immunity, N. gonorrhoeae has evolved systems to hijack zinc and other metals directly from host metal-binding proteins such as calprotectin (CP). Here, we report the 6.1 Å cryoEM structure of the gonococcal surface receptor TdfH in complex with a zinc-bound CP tetramer. We further show that TdfH can also interact with CP in the presence of copper and manganese, but not with cobalt.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Outer Membrane Proteins / Zinc / Leukocyte L1 Antigen Complex / Neisseria gonorrhoeae Type of study: Prognostic_studies Language: En Journal: Commun Biol Year: 2022 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Outer Membrane Proteins / Zinc / Leukocyte L1 Antigen Complex / Neisseria gonorrhoeae Type of study: Prognostic_studies Language: En Journal: Commun Biol Year: 2022 Document type: Article Affiliation country: United States