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Near UV and Visible Light Photo-Degradation Mechanisms in Citrate Buffer: One-Electron Reduction of Peptide and Protein Disulfides promotes Oxidation and Cis/Trans Isomerization of Unsaturated Fatty Acids of Polysorbate 80.
Prajapati, Indira; Subelzu, Natalia; Zhang, Yilue; Wu, Yaqi; Schöneich, Christian.
Affiliation
  • Prajapati I; Department of Pharmaceutical Chemistry, The University of Kansas, 2093 Constant Avenue, Lawrence, KS 66047, USA.
  • Subelzu N; Department of Pharmaceutical Chemistry, The University of Kansas, 2093 Constant Avenue, Lawrence, KS 66047, USA.
  • Zhang Y; Department of Pharmaceutical Chemistry, The University of Kansas, 2093 Constant Avenue, Lawrence, KS 66047, USA.
  • Wu Y; Department of Pharmaceutical Chemistry, The University of Kansas, 2093 Constant Avenue, Lawrence, KS 66047, USA.
  • Schöneich C; Department of Pharmaceutical Chemistry, The University of Kansas, 2093 Constant Avenue, Lawrence, KS 66047, USA. Electronic address: schoneic@ku.edu.
J Pharm Sci ; 111(4): 991-1003, 2022 04.
Article in En | MEDLINE | ID: mdl-35108563
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polysorbates / Disulfides Language: En Journal: J Pharm Sci Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polysorbates / Disulfides Language: En Journal: J Pharm Sci Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States