Therapeutic Potential of HNF4α in End-stage Liver Disease.
Organogenesis
; 17(3-4): 126-135, 2021 10 02.
Article
in En
| MEDLINE
| ID: mdl-35114889
ABSTRACT
The prevalence of end-stage liver disease (ESLD) in the US is increasing at an alarming rate. It can be caused by several factors; however, one of the most common routes begins with nonalcoholic fatty liver disease (NAFLD). ESLD is diagnosed by the presence of irreversible damage to the liver. Currently, the only definitive treatment for ESLD is orthotopic liver transplantation (OLT). Nevertheless, OLT is limited due to a shortage of donor livers. Several promising alternative treatment options are under investigation. Researchers have focused on the effect of liver-enriched transcription factors (LETFs) on disease progression. Specifically, hepatocyte nuclear factor 4-alpha (HNF4α) has been reported to reset the liver transcription network and possibly play a role in the regression of fibrosis and cirrhosis. In this review, we describe the function of HNF4α, along with its regulation at various levels. In addition, we summarize the role of HNF4α in ESLD and its potential as a therapeutic target in the treatment of ESLD.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Liver Transplantation
/
End Stage Liver Disease
/
Non-alcoholic Fatty Liver Disease
Type of study:
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Organogenesis
Year:
2021
Document type:
Article
Affiliation country:
United States