CCR7-guided neutrophil redirection to skin-draining lymph nodes regulates cutaneous inflammation and infection.
Sci Immunol
; 7(68): eabi9126, 2022 02 04.
Article
in En
| MEDLINE
| ID: mdl-35119939
ABSTRACT
Neutrophils are the first nonresident effector immune cells that migrate to a site of infection or inflammation; however, improper control of neutrophil responses can cause considerable tissue damage. Here, we found that neutrophil responses in inflamed or infected skin were regulated by CCR7-dependent migration and phagocytosis of neutrophils in draining lymph nodes (dLNs). In mouse models of Toll-like receptor-induced skin inflammation and cutaneous Staphylococcus aureus infection, neutrophils migrated from the skin to the dLNs via lymphatic vessels in a CCR7-mediated manner. In the dLNs, these neutrophils were phagocytosed by lymph node-resident type 1 and type 2 conventional dendritic cells. CCR7 up-regulation on neutrophils was a conserved mechanism across different tissues and was induced by a broad range of microbial stimuli. In the context of cutaneous immune responses, disruption of CCR7 interactions by selective CCR7 deficiency of neutrophils resulted in increased antistaphylococcal immunity and aggravated skin inflammation. Thus, neutrophil homing to and clearance in skin-dLNs affects cutaneous immunity versus pathology.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin
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Staphylococcal Infections
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Receptors, CCR7
/
Inflammation
/
Lymph Nodes
/
Neutrophils
Limits:
Animals
Language:
En
Journal:
Sci Immunol
Year:
2022
Document type:
Article
Affiliation country:
Switzerland
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
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US
/
USA