Design, chemical synthesis and antiviral evaluation of 2'-deoxy-2'-fluoro-2'-C-methyl-4'-thionucleosides.

Guinan, Mieke; Huang, Ningwu; Smith, Mark; Miller, Gavin J

Guinan, Mieke; Huang, Ningwu; Smith, Mark; Miller, Gavin J.

Affiliation

Guinan M; Lennard-Jones Laboratory, School of Chemical and Physical Sciences, Keele University, Keele, Staffordshire, ST5 5BG, United Kingdom; Centre for Glycoscience Research, Keele University, Keele, Staffordshire, ST5 5BG, United Kingdom.
Huang N; Riboscience LLC, 428 Oakmead Pkwy, Sunnyvale, CA 94085, USA.
Smith M; Riboscience LLC, 428 Oakmead Pkwy, Sunnyvale, CA 94085, USA.
Miller GJ; Lennard-Jones Laboratory, School of Chemical and Physical Sciences, Keele University, Keele, Staffordshire, ST5 5BG, United Kingdom; Centre for Glycoscience Research, Keele University, Keele, Staffordshire, ST5 5BG, United Kingdom. Electronic address: g.j.miller@keele.ac.uk.

Bioorg Med Chem Lett ; 61: 128605, 2022 04 01.

Article in En | MEDLINE | ID: mdl-35123007

Subject(s)

Antiviral Agents/pharmacology; Drug Design; Hepacivirus/drug effects; Thionucleosides/pharmacology; Antiviral Agents/chemical synthesis; Antiviral Agents/chemistry; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Thionucleosides/chemical synthesis; Thionucleosides/chemistry; Virus Replication/drug effects

Key words

Antiviral; Chemical synthesis; Nucleoside analogue; Sofosbuvir; Thionucleoside

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Thionucleosides / Drug Design / Hepacivirus Type of study: Prognostic_studies Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2022 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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