Chitosan and polyhexamethylene guanidine dual-functionalized cotton gauze as a versatile bandage for the management of chronic wounds.
Carbohydr Polym
; 282: 119130, 2022 Apr 15.
Article
in En
| MEDLINE
| ID: mdl-35123752
ABSTRACT
Development of versatile medical dressing with good immediate and long-lasting antibacterial, hygroscopic and moisturizing abilities is of great significance for management of chronic wounds. Cotton gauze (CG) can protect wounds and promote scabbing, but can cause wound dehydration and loss of biologically active substances, thereby greatly delays wound healing. Herein, a bi-functional CG dressing (CPCG) was developed by chemically grafting polyhexamethylene guanidine (PHMG) and physically adsorbing chitosan (CS) onto the CG surface. Due to the powerful microbicidal activity of PHMG, CPCG exhibited excellent immediate and long-lasting antibacterial activity against gram-positive and gram-negative bacteria. Moreover, the abundant hydroxyl and amino groups in CS endowed CPCG with good biocompatibility, moisture absorption, moisturizing and cell scratch healing performances. Importantly, CPCG can be easily fabricated into a bandage to conveniently manage infected full-skin wounds. Together, this study suggests that CPCG is a versatile wound dressing, having enormous application potential for management chronic wounds.
Key words
Acetic acid (PubChem CID: 176); Antibacterial; Chitosan; Chitosan (PubChem CID: 71853); Chronic wounds; Cotton gauze; Moist wound healing; PHMG; Polyhexamethylene guanidine hydrochloride (PubChem CID: 14771682); Sodium cyanoborohydride (PubChem CID: 20587905); Sodium periodate (PubChem CID: 23667635); Triethylamine (PubChem CID: 8471)
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bandages
/
Cotton Fiber
/
Chitosan
/
Guanidines
/
Anti-Bacterial Agents
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
Carbohydr Polym
Year:
2022
Document type:
Article
Publication country:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM