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Targeting AraC-Resistant Acute Myeloid Leukemia by Dual Inhibition of CDK9 and Bcl-2: A Systematic Review and Meta-Analysis.
Li, Linzhang; Han, Chengwu; Yu, Xueying; Shen, Jun; Cao, Yongtong.
Affiliation
  • Li L; Department of Laboratory Medicine, China-Japan Friendship Hospital, Beijing, China.
  • Han C; Department of Laboratory Medicine, China-Japan Friendship Hospital, Beijing, China.
  • Yu X; Department of Laboratory Medicine, China-Japan Friendship Hospital, Beijing, China.
  • Shen J; Department of Laboratory Medicine, China-Japan Friendship Hospital, Beijing, China.
  • Cao Y; Department of Laboratory Medicine, China-Japan Friendship Hospital, Beijing, China.
J Healthc Eng ; 2022: 2842066, 2022.
Article in En | MEDLINE | ID: mdl-35126914
ABSTRACT

PURPOSE:

This study aims to determine the influence of targeting araC-resistant acute myeloid leukemia by dual inhibition cyclin-dependent protein kinase (CDK9) and B-cell lymphoma-2 （Bcl-2).

METHOD:

The c-Myc inhibitor 10058-F4 and the CDK9 inhibitor AZD4573 were used to determine the cell cycle arrest and apoptosis.

RESULTS:

10058-F4 reduces c-Myc protein levels and suppresses HepG2 cell proliferation, possibly by upregulating cyclin-dependent kinase (CDK) inhibitors, p21WAF1, and reducing intracellular alpha-fetal protein (AFP) levels.

CONCLUSION:

The combination of AZD4573 and 10058-F4 has a synergistic anti-araC-resistant AML activity, providing a solid database for the aforementioned scientific hypothesis.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Antineoplastic Agents Type of study: Systematic_reviews Limits: Humans Language: En Journal: J Healthc Eng Year: 2022 Document type: Article Affiliation country: China Publication country: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Antineoplastic Agents Type of study: Systematic_reviews Limits: Humans Language: En Journal: J Healthc Eng Year: 2022 Document type: Article Affiliation country: China Publication country: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM