Your browser doesn't support javascript.
loading
Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.
McDowell, Colleen M; Kizhatil, Krishnakumar; Elliott, Michael H; Overby, Darryl R; van Batenburg-Sherwood, Joseph; Millar, J Cameron; Kuehn, Markus H; Zode, Gulab; Acott, Ted S; Anderson, Michael G; Bhattacharya, Sanjoy K; Bertrand, Jacques A; Borras, Terete; Bovenkamp, Diane E; Cheng, Lin; Danias, John; De Ieso, Michael Lucio; Du, Yiqin; Faralli, Jennifer A; Fuchshofer, Rudolf; Ganapathy, Preethi S; Gong, Haiyan; Herberg, Samuel; Hernandez, Humberto; Humphries, Peter; John, Simon W M; Kaufman, Paul L; Keller, Kate E; Kelley, Mary J; Kelly, Ruth A; Krizaj, David; Kumar, Ajay; Leonard, Brian C; Lieberman, Raquel L; Liton, Paloma; Liu, Yutao; Liu, Katy C; Lopez, Navita N; Mao, Weiming; Mavlyutov, Timur; McDonnell, Fiona; McLellan, Gillian J; Mzyk, Philip; Nartey, Andrews; Pasquale, Louis R; Patel, Gaurang C; Pattabiraman, Padmanabhan P; Peters, Donna M; Raghunathan, Vijaykrishna; Rao, Ponugoti Vasantha.
Affiliation
  • McDowell CM; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
  • Kizhatil K; The Jackson Laboratory, Bar Harbor, Maine, United States.
  • Elliott MH; University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
  • Overby DR; Department of Bioengineering, Imperial College London, United Kingdom.
  • van Batenburg-Sherwood J; Department of Bioengineering, Imperial College London, United Kingdom.
  • Millar JC; Department of Pharmacology & Neuroscience, and North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas, United States.
  • Kuehn MH; Department of Ophthalmology and Visual Sciences and Institute for Vision Research, The University of Iowa; Center for the Prevention and Treatment of Visual Loss, Veterans Affairs Medical Center, Iowa City, Iowa, United States.
  • Zode G; Department of Pharmacology & Neuroscience, and North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas, United States.
  • Acott TS; Ophthalmology and Biochemistry and Molecular Biology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States.
  • Anderson MG; Department of Molecular Physiology and Biophysics and Department of Ophthalmology and Visual Sciences, The University of Iowa; Center for the Prevention and Treatment of Visual Loss, Veterans Affairs Medical Center, Iowa City, Iowa, United States.
  • Bhattacharya SK; Bascom Palmer Eye Institute, University of Miami, Miami, Florida, United States.
  • Bertrand JA; Department of Bioengineering, Imperial College London, London, United Kingdom.
  • Borras T; University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
  • Bovenkamp DE; Brightfocus Foundation, Clarksburg, Maryland, United States.
  • Cheng L; Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, United States.
  • Danias J; SUNY Downstate Health Sciences University, Brooklyn, New York, United States.
  • De Ieso ML; Department of Ophthalmology, Duke Eye Center, Duke University, Durham, North Carolina, United States.
  • Du Y; Department of Ophthalmology, University of Pittsburgh, Pennsylvania, United States.
  • Faralli JA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.
  • Fuchshofer R; Institute of Human Anatomy and Embryology, University of Regensburg, Regensburg, Germany.
  • Ganapathy PS; Department of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, New York, United States.
  • Gong H; Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, United States.
  • Herberg S; Department of Ophthalmology and Visual Sciences, SUNY Upstate Medical University, Syracuse, New York, United States.
  • Hernandez H; University of Houston-Victoria, Victoria, Texas, United States.
  • Humphries P; Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
  • John SWM; Department of Ophthalmology, Columbia University, New York, New York, United States.
  • Kaufman PL; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
  • Keller KE; Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States.
  • Kelley MJ; Department of Ophthalmology and Department of Integrative Biosciences, Oregon Health & Science University, Portland, Oregon, United States.
  • Kelly RA; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.
  • Krizaj D; Department of Ophthalmology, University of Utah School of Medicine, Salt Lake City, Utah, United States.
  • Kumar A; Department of Ophthalmology, University of Pittsburgh, Pennsylvania, United States.
  • Leonard BC; Department of Surgical and Radiological Sciences, University of California, Davis, Davis, California, United States.
  • Lieberman RL; Department of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, United States.
  • Liton P; Department of Ophthalmology and Department of Pathology, Duke University, Durham, North Carolina, United States.
  • Liu Y; Department of Cellular Biology and Anatomy, James & Jean Culver Vision Discovery Institute, Augusta University, Augusta, Georgia, United States.
  • Liu KC; Duke Eye Center, Duke Health, Durham, North Carolina, United States.
  • Lopez NN; Department of Neurobiology, University of Utah, Salt Lake City, Utah, United States.
  • Mao W; Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States.
  • Mavlyutov T; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
  • McDonnell F; Duke Eye Center, Duke Health, Durham, North Carolina, United States.
  • McLellan GJ; Department of Surgical Sciences and Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
  • Mzyk P; Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States.
  • Nartey A; College of Optometry, University of Houston, Houston, Texas, United States.
  • Pasquale LR; Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, United States.
  • Patel GC; Ophthalmology Research, Regeneron Pharmaceuticals, Tarreytown, New York, United States.
  • Pattabiraman PP; Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States.
  • Peters DM; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.
  • Raghunathan V; College of Optometry, University of Houston, Houston, Texas, United States.
  • Rao PV; Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, United States.
Invest Ophthalmol Vis Sci ; 63(2): 12, 2022 02 01.
Article in En | MEDLINE | ID: mdl-35129590
ABSTRACT
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aqueous Humor / Trabecular Meshwork / Glaucoma / Ocular Hypertension / Consensus / Intraocular Pressure Type of study: Guideline / Prognostic_studies Limits: Animals Language: En Journal: Invest Ophthalmol Vis Sci Year: 2022 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aqueous Humor / Trabecular Meshwork / Glaucoma / Ocular Hypertension / Consensus / Intraocular Pressure Type of study: Guideline / Prognostic_studies Limits: Animals Language: En Journal: Invest Ophthalmol Vis Sci Year: 2022 Document type: Article Affiliation country: United States