Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.
Invest Ophthalmol Vis Sci
; 63(2): 12, 2022 02 01.
Article
in En
| MEDLINE
| ID: mdl-35129590
ABSTRACT
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aqueous Humor
/
Trabecular Meshwork
/
Glaucoma
/
Ocular Hypertension
/
Consensus
/
Intraocular Pressure
Type of study:
Guideline
/
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Invest Ophthalmol Vis Sci
Year:
2022
Document type:
Article
Affiliation country:
United States