Inhibitory effects and underlying mechanisms of Artemisia capillaris essential oil on melanogenesis in the B16F10 cell line.
Mol Med Rep
; 25(4)2022 Apr.
Article
in En
| MEDLINE
| ID: mdl-35137924
ABSTRACT
The present study investigated the antimelanogenic activity of 10 essential oils using the B16F10 cell model. Initially, a wide range of concentrations of these essential oils were screened in order to determine their toxicity levels. The assigned nontoxic concentrations of the tested essential oils were then used to evaluate their effects on melanogenesis. The effects of the essential oils with potent antimelanogenic activity on cell proliferation, protection against H2O2induced cell death and the expression of certain melanogenesisrelated genes, including MITF, tyrosinase, tyrosinase related protein (TRP)1 and TRP2 were also evaluated. The results revealed that the essential oils extracted from Citrus unshiu, Juniperus chinensis L., Zanthoxylum piperitum and Artemisia capillaris (A. capillaris) inhibited melanogenesis. However, among these four extracts, only A. capillaris extract enhanced cell proliferation, exhibited antiH2O2 activities and decreased the expression level of TRP1. It was demonstrated that A. capillaris extract inhibited melanin synthesis via the downregulation of the TRP1 translational level. These essential oil extracts, particularly that of A. capillaris, may thus be used as natural antimelanogenic agents for therapeutic purposes and in the cosmetic industry for skin whitening effects with beneficial proliferative properties. However, further studies using in vivo models are required to validate these findings and to examine the effects of these extracts on various molecular pathways.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Melanoma, Experimental
/
Oils, Volatile
/
Artemisia
/
Protective Agents
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Mol Med Rep
Year:
2022
Document type:
Article