Quercetin Reduces Lipid Accumulation in a Cell Model of NAFLD by Inhibiting De Novo Fatty Acid Synthesis through the Acetyl-CoA Carboxylase 1/AMPK/PP2A Axis.

Gnoni, Antonio; Di Chiara Stanca, Benedetta; Giannotti, Laura; Gnoni, Gabriele Vincenzo; Siculella, Luisa; Damiano, Fabrizio

Gnoni, Antonio; Di Chiara Stanca, Benedetta; Giannotti, Laura; Gnoni, Gabriele Vincenzo; Siculella, Luisa; Damiano, Fabrizio.

Affiliation

Gnoni A; Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro", 70121 Bari, Italy.
Di Chiara Stanca B; Laboratory of Molecular Biology, Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy.
Giannotti L; Laboratory of Molecular Biology, Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy.
Gnoni GV; Laboratory of Biological Chemistry, Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy.
Siculella L; Laboratory of Molecular Biology, Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy.
Damiano F; Laboratory of Molecular Biology, Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy.

Int J Mol Sci ; 23(3)2022 Jan 18.

Article in En | MEDLINE | ID: mdl-35162967

Subject(s)

Acetyl-CoA Carboxylase/metabolism; Fatty Acids/metabolism; Non-alcoholic Fatty Liver Disease/metabolism; Quercetin/pharmacology; AMP-Activated Protein Kinases/metabolism; Acetyl-CoA Carboxylase/genetics; Gene Expression Profiling; Hep G2 Cells; Humans; Lipogenesis; Models, Biological; Non-alcoholic Fatty Liver Disease/drug therapy; Non-alcoholic Fatty Liver Disease/genetics; Phosphorylation; Protein Phosphatase 2/metabolism; Signal Transduction

Key words

AMP-activated protein kinase; acetyl-CoA carboxylase 1; citrate carrier; de novo lipogenesis; endoplasmic reticulum stress; non-alcoholic fatty liver disease; protein phosphatase 2A; quercetin; sterol regulatory element-binding protein 1

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetyl-CoA Carboxylase / Quercetin / Fatty Acids / Non-alcoholic Fatty Liver Disease Type of study: Prognostic_studies Limits: Humans Language: En Journal: Int J Mol Sci Year: 2022 Document type: Article Affiliation country: Italy

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google