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LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria.
Yang, Qiyuan; Liu, Pengpeng; Anderson, Nadine S; Shpilka, Tomer; Du, YunGuang; Naresh, Nandhitha Uma; Li, Rui; Zhu, Lihua Julie; Luk, Kevin; Lavelle, Josh; Zeinert, Rilee D; Chien, Peter; Wolfe, Scot A; Haynes, Cole M.
Affiliation
  • Yang Q; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Liu P; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Anderson NS; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Shpilka T; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Du Y; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Naresh NU; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Li R; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Zhu LJ; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Luk K; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Lavelle J; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
  • Zeinert RD; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA, USA.
  • Chien P; Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, MA, USA.
  • Wolfe SA; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, Amherst, MA, USA.
  • Haynes CM; Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, MA, USA.
Nat Cell Biol ; 24(2): 181-193, 2022 02.
Article in En | MEDLINE | ID: mdl-35165413
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidative Phosphorylation / Transcription Factors / DNA, Mitochondrial / Caenorhabditis elegans / Caenorhabditis elegans Proteins / Mitochondrial Proteins / ATP-Dependent Proteases / DNA Replication / Heteroplasmy / Mitochondria Limits: Animals / Humans Language: En Journal: Nat Cell Biol Year: 2022 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxidative Phosphorylation / Transcription Factors / DNA, Mitochondrial / Caenorhabditis elegans / Caenorhabditis elegans Proteins / Mitochondrial Proteins / ATP-Dependent Proteases / DNA Replication / Heteroplasmy / Mitochondria Limits: Animals / Humans Language: En Journal: Nat Cell Biol Year: 2022 Document type: Article Affiliation country: United States