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-808 nm-activated Ca2+doped up-conversion nanoparticles that release no inducing liver cancer cell (HepG2) apoptosis.
Fa, Xinmeng; Lin, Shaowei; Yang, Jianghua; Shen, Chong; Liu, Yuanli; Gong, Yongyang; Qin, Aimiao; Ou, Jun; Resch-Genger, Ute.
Affiliation
  • Fa X; Materials Science and Engineering College, Guilin University of Technology, 541004 Guilin, People's Republic of China.
  • Lin S; Materials Science and Engineering College, Guilin University of Technology, 541004 Guilin, People's Republic of China.
  • Yang J; Materials Science and Engineering College, Guilin University of Technology, 541004 Guilin, People's Republic of China.
  • Shen C; Dental Clinic and Experimental Center of Medical Sciences, Guilin Medical University, 541002 Guilin, People's Republic of China.
  • Liu Y; Materials Science and Engineering College, Guilin University of Technology, 541004 Guilin, People's Republic of China.
  • Gong Y; Materials Science and Engineering College, Guilin University of Technology, 541004 Guilin, People's Republic of China.
  • Qin A; Materials Science and Engineering College, Guilin University of Technology, 541004 Guilin, People's Republic of China.
  • Ou J; Materials Science and Engineering College, Guilin University of Technology, 541004 Guilin, People's Republic of China.
  • Resch-Genger U; Federal Institute for Materials Research and Testing, Division Biophotonics, Richard-Willstätter-Str. 11,12489 Berlin, Germany.
Methods Appl Fluoresc ; 10(2)2022 Feb 23.
Article in En | MEDLINE | ID: mdl-35168212
A near-infrared (NIR) light-triggered release method for nitric oxide (NO) was developed utilizing core/shell NaYF4: Tm/Yb/Ca@NaGdF4: Nd/Yb up-conversion nanoparticles (UCNPs) bearing a mesoporous silica (mSiO2) shell loaded with the NO donor S-nitroso-N-acetyl-DL-penicillamine (SNAP). To avoid overheating in biological samples, Nd3+was chosen as a sensitizer, Yb3+ions as the bridging sensitizer, and Tm3+ions as UV-emissive activator while co-doping with Ca2+was done to enhance the luminescence of the activator Tm3+. NO release from SNAP was triggered by an NIR-UV up-conversion process, initiated by 808 nm light absorbed by the Nd3+ions. NO release was confirmed by the Griess method. Under 808 nm irradiation, the viability of the liver cancer cell line HepG2 significantly decreased with increasing UCNPs@mSiO2-SNAP concentration. For a UCNPs@mSiO2-SNAP concentration of 200µg ml-1, the cell survival probability was 47%. These results demonstrate that UCNPs@mSiO2-SNAP can induce the release of apoptosis-inducing NO by NIR irradiation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nanoparticles / Liver Neoplasms Limits: Humans Language: En Journal: Methods Appl Fluoresc Year: 2022 Document type: Article Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nanoparticles / Liver Neoplasms Limits: Humans Language: En Journal: Methods Appl Fluoresc Year: 2022 Document type: Article Country of publication: United kingdom