Deep transcranial magnetic stimulation in combination with skin thermography in obesity: a window on sympathetic nervous system.
Acta Diabetol
; 59(5): 729-742, 2022 May.
Article
in En
| MEDLINE
| ID: mdl-35174415
ABSTRACT
AIMS:
Obesity is known to be associated with an altered thermoregulation as well as a dysregulation of sympathetic nervous system (SNS). Considering the ability of deep transcranial magnetic stimulation (dTMS) to modulate the SNS, we hypothesized a potential role of dTMS in affecting thermoregulation in obesity. Aims of the study were to monitor the effect of a single session of dTMS on body temperature in subjects with obesity, and to correlate the dTMS-induced changes in body temperature with activation of the SNS (epinephrine and norepinephrine release).METHODS:
Twenty-nine subjects with obesity [5 M, 24 F; age 50 (IQR 58, 38) yrs; BMI 36.1 (IQR 33.9, 38.7) kg/m2] were randomized into 2 groups receiving a single session of high frequency stimulation (HF) or sham stimulation. Under neutral thermal conditions, infrared thermography was utilized to assess bilateral fingernail-beds and abdominal temperature.RESULTS:
During a single session HF, the average temperature of both fingernail-beds decreased. Right-hand temperature difference was statistically greater in HF vs Sham median = - 1.45 (IQR - 2.0, - 1.0) °C for HF, p = 0.009. While temperature variation in the fingernail-bed of left hand was not statistically significant in HF compared to Sham median = - 1.26 (IQR - 1.6, -0.5) °C, p = 0.064. Concurrently, when estimating the effect of norepinephrine variation on temperature change of fingernail-bed of left hand, a borderline significant positive association was estimated (beta = 1.09, p = 0.067) in HF.CONCLUSIONS:
Deep TMS revealed to be effective in modulating temperature in subjects with obesity, partially reversing obesity-induced alterations in heat production and dissipation with a potential SNS-mediated mechanism.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thermography
/
Transcranial Magnetic Stimulation
Type of study:
Clinical_trials
Limits:
Humans
/
Middle aged
Language:
En
Journal:
Acta Diabetol
Journal subject:
ENDOCRINOLOGIA
Year:
2022
Document type:
Article
Affiliation country:
Italy