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Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis.
Jiao, Yan; Nan, Jinshan; Mu, Bo; Zhang, Yun; Zhou, Nenghua; Yang, Shunhua; Zhang, Shanshan; Lin, Wanting; Wang, Falu; Xia, Anjie; Cao, Zhixing; Chen, Pei; Pan, Zhiling; Lin, Guifeng; Pan, Shulei; Bin, Huachao; Li, Linli; Yang, Shengyong.
Affiliation
  • Jiao Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, And Collaborative Innovation Center for Biotherapy, Sichuan University, Sichuan, 610041, China.
  • Nan J; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, And Collaborative Innovation Center for Biotherapy, Sichuan University, Sichuan, 610041, China.
  • Mu B; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, And Collaborative Innovation Center for Biotherapy, Sichuan University, Sichuan, 610041, China; Basic Medical College of North Sichuan Medical College, Nanchong, Sichuan, 637000, China.
  • Zhang Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, And Collaborative Innovation Center for Biotherapy, Sichuan University, Sichuan, 610041, China; Research Laboratory of Macular Disease, Department of Ophthalmology, West China Hospital, Sichuan University, Sichuan, 610041, Ch
  • Zhou N; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Sichuan, 610041, China.
  • Yang S; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, And Collaborative Innovation Center for Biotherapy, Sichuan University, Sichuan, 610041, China.
  • Zhang S; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, And Collaborative Innovation Center for Biotherapy, Sichuan University, Sichuan, 610041, China.
  • Lin W; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, And Collaborative Innovation Center for Biotherapy, Sichuan University, Sichuan, 610041, China.
  • Wang F; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, And Collaborative Innovation Center for Biotherapy, Sichuan University, Sichuan, 610041, China.
  • Xia A; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, And Collaborative Innovation Center for Biotherapy, Sichuan University, Sichuan, 610041, China.
  • Cao Z; State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Sichuan, 610041, China.
  • Chen P; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Sichuan, 610041, China.
  • Pan Z; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, And Collaborative Innovation Center for Biotherapy, Sichuan University, Sichuan, 610041, China.
  • Lin G; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, And Collaborative Innovation Center for Biotherapy, Sichuan University, Sichuan, 610041, China.
  • Pan S; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, And Collaborative Innovation Center for Biotherapy, Sichuan University, Sichuan, 610041, China.
  • Bin H; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, And Collaborative Innovation Center for Biotherapy, Sichuan University, Sichuan, 610041, China.
  • Li L; Key Laboratory of Drug Targeting and Drug Delivery System of Ministry of Education, West China School of Pharmacy, Sichuan University, Sichuan, 610041, China. Electronic address: lilinli@scu.edu.cn.
  • Yang S; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, And Collaborative Innovation Center for Biotherapy, Sichuan University, Sichuan, 610041, China. Electronic address: yangsy@scu.edu.cn.
Eur J Med Chem ; 232: 114194, 2022 Mar 15.
Article in En | MEDLINE | ID: mdl-35183871
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / Inflammasomes Limits: Animals Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article Affiliation country: China Country of publication: France
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Diabetes Mellitus, Type 2 / Inflammasomes Limits: Animals Language: En Journal: Eur J Med Chem Year: 2022 Document type: Article Affiliation country: China Country of publication: France