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The collectrin-like part of the SARS-CoV-1 and -2 receptor ACE2 is shed by the metalloproteinases ADAM10 and ADAM17.
Niehues, Rabea Victoria; Wozniak, Justyna; Wiersch, Florian; Lilienthal, Eva; Tacken, Nikola; Schumertl, Tim; Garbers, Christoph; Ludwig, Andreas; Düsterhöft, Stefan.
Affiliation
  • Niehues RV; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Wozniak J; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Wiersch F; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Lilienthal E; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Tacken N; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Schumertl T; Department of Pathology, Medical Faculty, Otto von Guericke University Magdeburg, Magdeburg, Germany.
  • Garbers C; Department of Pathology, Medical Faculty, Otto von Guericke University Magdeburg, Magdeburg, Germany.
  • Ludwig A; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Düsterhöft S; Institute of Molecular Pharmacology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
FASEB J ; 36(3): e22234, 2022 03.
Article in En | MEDLINE | ID: mdl-35199397
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Severe acute respiratory syndrome-related coronavirus / Amyloid Precursor Protein Secretases / Extracellular Vesicles / ADAM10 Protein / ADAM17 Protein / Angiotensin-Converting Enzyme 2 / Membrane Proteins Limits: Humans Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2022 Document type: Article Affiliation country: Germany
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Severe acute respiratory syndrome-related coronavirus / Amyloid Precursor Protein Secretases / Extracellular Vesicles / ADAM10 Protein / ADAM17 Protein / Angiotensin-Converting Enzyme 2 / Membrane Proteins Limits: Humans Language: En Journal: FASEB J Journal subject: BIOLOGIA / FISIOLOGIA Year: 2022 Document type: Article Affiliation country: Germany