Chitosan and Hyaluronic Acid Nanoparticles as Vehicles of Epoetin Beta for Subconjunctival Ocular Delivery.

Silva, Beatriz; Gonçalves, Lídia M; Braz, Berta São; Delgado, Esmeralda

Silva, Beatriz; Gonçalves, Lídia M; Braz, Berta São; Delgado, Esmeralda.

Affiliation

Silva B; CIISA-Centre for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Avenida da Universidade Técnica, 1300-477 Lisbon, Portugal.
Gonçalves LM; Associate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), 1300-477 Lisbon, Portugal.
Braz BS; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, 1600-277 Lisbon, Portugal.
Delgado E; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, 1600-277 Lisbon, Portugal.

Mar Drugs ; 20(2)2022 Feb 18.

Article in En | MEDLINE | ID: mdl-35200680

Subject(s)

Chitosan/chemistry; Erythropoietin/pharmacokinetics; Hyaluronic Acid/chemistry; Nanoparticles; Animals; Drug Carriers/chemistry; Drug Delivery Systems; Erythropoietin/administration & dosage; Erythropoietin/toxicity; Eye/metabolism; Male; Rats; Rats, Wistar; Recombinant Proteins/administration & dosage; Recombinant Proteins/pharmacokinetics; Recombinant Proteins/toxicity; Retina/metabolism; Time Factors

Key words

chitosan; epoetin beta; erythropoietin; hyaluronic acid; mucoadhesion; nanoparticles; ocular delivery

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Erythropoietin / Chitosan / Nanoparticles / Hyaluronic Acid Limits: Animals Language: En Journal: Mar Drugs Journal subject: BIOLOGIA / FARMACOLOGIA Year: 2022 Document type: Article Affiliation country: Portugal Country of publication: Switzerland

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