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Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2.
Singh, Ranjan K; Soliman, Ahmed; Guaitoli, Giambattista; Störmer, Eliza; von Zweydorf, Felix; Dal Maso, Thomas; Oun, Asmaa; Van Rillaer, Laura; Schmidt, Sven H; Chatterjee, Deep; David, Joshua A; Pardon, Els; Schwartz, Thomas U; Knapp, Stefan; Kennedy, Eileen J; Steyaert, Jan; Herberg, Friedrich W; Kortholt, Arjan; Gloeckner, Christian Johannes; Versées, Wim.
Affiliation
  • Singh RK; VIB-VUB Center for Structural Biology, 1050 Brussels, Belgium.
  • Soliman A; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
  • Guaitoli G; Department of Cell Biochemistry, University of Groningen, 9747AG Groningen, The Netherlands.
  • Störmer E; German Center for Neurodegenerative Diseases, D-72076 Tübingen, Germany.
  • von Zweydorf F; Department of Biochemistry, Institute for Biology, University of Kassel, 34132 Kassel, Germany.
  • Dal Maso T; German Center for Neurodegenerative Diseases, D-72076 Tübingen, Germany.
  • Oun A; VIB-VUB Center for Structural Biology, 1050 Brussels, Belgium.
  • Van Rillaer L; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
  • Schmidt SH; Department of Cell Biochemistry, University of Groningen, 9747AG Groningen, The Netherlands.
  • Chatterjee D; Groningen Research Institute of Pharmacy, Molecular Pharmacology XB10, 9700AD Groningen, The Netherlands.
  • David JA; VIB-VUB Center for Structural Biology, 1050 Brussels, Belgium.
  • Pardon E; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
  • Schwartz TU; Department of Biochemistry, Institute for Biology, University of Kassel, 34132 Kassel, Germany.
  • Knapp S; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, 60438 Frankfurt, Germany.
  • Kennedy EJ; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Goethe-University Frankfurt, 60438 Frankfurt, Germany.
  • Steyaert J; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Herberg FW; VIB-VUB Center for Structural Biology, 1050 Brussels, Belgium.
  • Kortholt A; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium.
  • Gloeckner CJ; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
  • Versées W; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, 60438 Frankfurt, Germany.
Proc Natl Acad Sci U S A ; 119(9)2022 03 01.
Article in En | MEDLINE | ID: mdl-35217606
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Single-Domain Antibodies / Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Document type: Article Affiliation country: Belgium Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / Single-Domain Antibodies / Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Type of study: Risk_factors_studies Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Document type: Article Affiliation country: Belgium Country of publication: United States