No Effect of Levothyroxine on Hemoglobin in Older Adults With Subclinical Hypothyroidism: Pooled Results From 2 Randomized Controlled Trials.
J Clin Endocrinol Metab
; 107(6): e2339-e2347, 2022 05 17.
Article
in En
| MEDLINE
| ID: mdl-35218666
ABSTRACT
CONTEXT Subclinical thyroid dysfunction and anemia are common disorders, and both have increasing prevalence with advancing age. OBJECTIVE:
The aim of this study was to assess whether levothyroxine treatment leads to a rise in hemoglobin levels in older persons with subclinical hypothyroidism.METHODS:
This preplanned combined analysis of 2 randomized controlled trials included community-dwelling persons aged 65 years and older with subclinical hypothyroidism who were randomly assigned to levothyroxine or placebo treatment. The levothyroxine dose was periodically titrated aiming at thyroid stimulating hormone (TSH) level within the reference range, with mock titrations in the placebo group. The main outcome measure was the change in hemoglobin level after 12 months.RESULTS:
Analyses included 669 participants (placebo nâ =â 337, levothyroxine nâ =â 332) with a median age of 75 years (range, 65-97) and mean baseline hemoglobin of 13.8â ±â 1.3 g/dL. Although levothyroxine treatment resulted in a reduction in TSH from baseline after 12 months of follow-up compared with placebo, the change in hemoglobin level was not different between the levothyroxine and the placebo groups (-0.03 g/dL [95% CI, -0.16 to 0.11]). Similar results were found in stratified analyses including sex, age, or TSH levels. No difference in change of hemoglobin levels after 12 months was identified in 69 participants with anemia at baseline (-0.33 g/dL [95% CI, -0.87 to 0.21]).CONCLUSION:
In persons aged 65 years and older with subclinical hypothyroidism, treatment with levothyroxine does not lead to a rise in hemoglobin levels, regardless of the presence of anemia.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thyroxine
/
Hypothyroidism
Type of study:
Clinical_trials
/
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Humans
Language:
En
Journal:
J Clin Endocrinol Metab
Year:
2022
Document type:
Article
Affiliation country:
Netherlands