Metformin reduces chondrocyte pyroptosis in an osteoarthritis mouse model by inhibiting NLRP3 inflammasome activation.

Yan, Jiangbo; Ding, Dong; Feng, Gangning; Yang, Yong; Zhou, Yong; Ma, Long; Guo, Haohui; Lu, Zhidong; Jin, Qunhua

Yan, Jiangbo; Ding, Dong; Feng, Gangning; Yang, Yong; Zhou, Yong; Ma, Long; Guo, Haohui; Lu, Zhidong; Jin, Qunhua.

Affiliation

Yan J; Clinical Medical School, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China.
Ding D; Clinical Medical School, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China.
Feng G; Clinical Medical School, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China.
Yang Y; Clinical Medical School, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China.
Zhou Y; Orthopedics Ward 3, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China.
Ma L; Clinical Medical School, Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China.
Guo H; Orthopedics Ward 3, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China.
Lu Z; Orthopedics Ward 3, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China.
Jin Q; Orthopedics Ward 3, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China.

Exp Ther Med ; 23(3): 222, 2022 Mar.

Article in En | MEDLINE | ID: mdl-35222699

Key words

NOD-like receptor protein 3; chondrocytes; metformin; osteoarthritis; pyroptosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Exp Ther Med Year: 2022 Document type: Article Country of publication: Greece

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