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Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides.
Bost, Jeremy P; Ojansivu, Miina; Munson, Michael J; Wesén, Emelie; Gallud, Audrey; Gupta, Dhanu; Gustafsson, Oskar; Saher, Osama; Rädler, Julia; Higgins, Stuart G; Lehto, Taavi; Holme, Margaret N; Dahlén, Anders; Engkvist, Ola; Strömstedt, Per-Erik; Andersson, Shalini; Edvard Smith, C I; Stevens, Molly M; Esbjörner, Elin K; Collén, Anna; El Andaloussi, Samir.
Affiliation
  • Bost JP; Department of Laboratory Medicine, Karolinska Institutet, Huddinge, 14157, Sweden. jeremy.bost@ki.se.
  • Ojansivu M; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, 17177, Sweden.
  • Munson MJ; Advanced Drug Delivery, Pharmaceutical Sciences, Biopharmaceutical R&D, AstraZeneca, Mölndal, 43150, Sweden.
  • Wesén E; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, 41296, Sweden.
  • Gallud A; Advanced Drug Delivery, Pharmaceutical Sciences, Biopharmaceutical R&D, AstraZeneca, Mölndal, 43150, Sweden.
  • Gupta D; Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, 41296, Sweden.
  • Gustafsson O; Department of Laboratory Medicine, Karolinska Institutet, Huddinge, 14157, Sweden.
  • Saher O; Department of Laboratory Medicine, Karolinska Institutet, Huddinge, 14157, Sweden.
  • Rädler J; Department of Laboratory Medicine, Karolinska Institutet, Huddinge, 14157, Sweden.
  • Higgins SG; Department of Pharmaceutics and Industrial Pharmacy, Cairo University, Cairo, 11562, Egypt.
  • Lehto T; Department of Laboratory Medicine, Karolinska Institutet, Huddinge, 14157, Sweden.
  • Holme MN; Department of Materials, Department of Bioengineering, Institute of Biomedical Engineering, Imperial College London, London, SW7 2AZ, United Kingdom.
  • Dahlén A; Department of Laboratory Medicine, Karolinska Institutet, Huddinge, 14157, Sweden.
  • Engkvist O; Institute of Technology, University of Tartu, Nooruse 1, Tartu, 50411, Estonia.
  • Strömstedt PE; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, 17177, Sweden.
  • Andersson S; Discovery Sciences, R&D, AstraZeneca, Gothenburg, 43150, Sweden.
  • Edvard Smith CI; Discovery Sciences, R&D, AstraZeneca, Gothenburg, 43150, Sweden.
  • Stevens MM; Discovery Sciences, R&D, AstraZeneca, Gothenburg, 43150, Sweden.
  • Esbjörner EK; Discovery Sciences, R&D, AstraZeneca, Gothenburg, 43150, Sweden.
  • Collén A; Department of Laboratory Medicine, Karolinska Institutet, Huddinge, 14157, Sweden.
  • El Andaloussi S; Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, 17177, Sweden.
Commun Biol ; 5(1): 185, 2022 03 01.
Article in En | MEDLINE | ID: mdl-35233031
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides / Oligonucleotides, Antisense Language: En Journal: Commun Biol Year: 2022 Document type: Article Affiliation country: Sweden Country of publication: United kingdom
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides / Oligonucleotides, Antisense Language: En Journal: Commun Biol Year: 2022 Document type: Article Affiliation country: Sweden Country of publication: United kingdom