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Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis.
LaMoia, Traci E; Butrico, Gina M; Kalpage, Hasini A; Goedeke, Leigh; Hubbard, Brandon T; Vatner, Daniel F; Gaspar, Rafael C; Zhang, Xian-Man; Cline, Gary W; Nakahara, Keita; Woo, Seungwan; Shimada, Atsuhiro; Hüttemann, Maik; Shulman, Gerald I.
Affiliation
  • LaMoia TE; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
  • Butrico GM; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06520.
  • Kalpage HA; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
  • Goedeke L; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI 48201.
  • Hubbard BT; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
  • Vatner DF; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
  • Gaspar RC; Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06520.
  • Zhang XM; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
  • Cline GW; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
  • Nakahara K; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
  • Woo S; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520.
  • Shimada A; Department of Applied Life Science, Gifu University, Gifu 501-1193, Japan.
  • Hüttemann M; Department of Applied Life Science, Gifu University, Gifu 501-1193, Japan.
  • Shulman GI; Department of Applied Life Science, Gifu University, Gifu 501-1193, Japan.
Proc Natl Acad Sci U S A ; 119(10): e2122287119, 2022 03 08.
Article in En | MEDLINE | ID: mdl-35238637

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenformin / Electron Transport Complex IV / Gluconeogenesis / Guanidines / Hypoglycemic Agents / Metformin Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenformin / Electron Transport Complex IV / Gluconeogenesis / Guanidines / Hypoglycemic Agents / Metformin Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 2022 Document type: Article Country of publication: United States