An overview of the current state of phage therapy for the treatment of biofilm-related infections.
Curr Opin Virol
; 53: 101209, 2022 04.
Article
in En
| MEDLINE
| ID: mdl-35240424
ABSTRACT
Bacterial biofilms are involved in many chronic and difficult-to-treat infections. Phage therapy against infectious biofilms is becoming a promising strategy, as suggested by the increasing number of publications demonstrating the efficacy of phages against in vitro formed biofilms. However, the translation between in vitro results to in vivo phage therapy outcome is not straightforward due to the complexity of phage-biofilm interactions in clinical contexts. Here, we provide a critical overview of the in vitro studies of phages for biofilm control of clinical pathogens, followed by the major outcomes and lessons learned from the recently reported case studies (between 2018 and 2021) of phage therapy against biofilm-related infections.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bacteriophages
/
Phage Therapy
Language:
En
Journal:
Curr Opin Virol
Year:
2022
Document type:
Article
Affiliation country:
Portugal