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BCL-XL PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRASG12C-mutated cancers.
Khan, Sajid; Wiegand, Janet; Zhang, Peiyi; Hu, Wanyi; Thummuri, Dinesh; Budamagunta, Vivekananda; Hua, Nan; Jin, Lingtao; Allegra, Carmen J; Kopetz, Scott E; Zajac-Kaye, Maria; Kaye, Frederic J; Zheng, Guangrong; Zhou, Daohong.
Affiliation
  • Khan S; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA. khansajid@cop.ufl.edu.
  • Wiegand J; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.
  • Zhang P; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA.
  • Hu W; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL, USA.
  • Thummuri D; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.
  • Budamagunta V; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.
  • Hua N; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA.
  • Jin L; Genetics and Genomics Graduate Program, Genetics Institute, College of Medicine, University of Florida, Gainesville, FL, USA.
  • Allegra CJ; Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL, 32610, USA.
  • Kopetz SE; Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL, USA.
  • Zajac-Kaye M; Division of Hematology and Oncology, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
  • Kaye FJ; Department of Gastrointestinal Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Zheng G; Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL, USA.
  • Zhou D; Division of Hematology and Oncology, Department of Medicine, College of Medicine, University of Florida, Gainesville, FL, USA.
J Hematol Oncol ; 15(1): 23, 2022 03 09.
Article in En | MEDLINE | ID: mdl-35260176
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Lung Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Hematol Oncol Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2022 Document type: Article Affiliation country: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carcinoma, Non-Small-Cell Lung / Lung Neoplasms Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Hematol Oncol Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2022 Document type: Article Affiliation country: United States