Particulate matter exposure during pregnancy increases risk of childhood asthma: modified by gender and NRF2 genotype.
Asian Pac J Allergy Immunol
; 41(3): 220-226, 2023 Sep.
Article
in En
| MEDLINE
| ID: mdl-35278062
ABSTRACT
BACKGROUND:
Exposure to particulate matter (PM) has been known to develop asthma in children and the oxidative stress-related mechanisms are suggested. For the development of asthma, not only the exposure dose but also the critical window and the risk modifying factors should be evaluated.OBJECTIVE:
We investigated whether prenatal exposure to PM10 increases the risk of childhood asthma and evaluated the modifying factors, such as gender and reactive oxidative stress-related gene.METHODS:
A general population-based birth cohort, the Panel Study of Korean Children (PSKC), including 1572 mother-baby dyads was analyzed. Children were defined to have asthma at age 7 when a parent reported physician-diagnosed asthma. Exposure to PM10 during pregnancy was estimated by land-use regression models based on national monitoring system. TaqMan method was used for genotyping nuclear factor, erythroid 2-related factor, NRF2 (rs6726395). A logistic Bayesian distributed lag interaction model (BDLIM) was used to evaluate the associations between prenatal PM10 exposure and childhood asthma by gender and NRF2.RESULTS:
Exposure to PM10 during pregnancy was associated with the development of asthma (aOR 1.03, 95% CI 1.001.06). Stratifying by gender and NRF2 genotype, exposure to PM10 during 26-28 weeks gestation increased the risk of childhood asthma, especially in boys with NRF2 GG genotype.CONCLUSIONS:
A critical window for PM10 exposure on the development of childhood asthma was during 26-28 weeks of gestation, and this was modified by gender and NRF2 genotype.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prenatal Exposure Delayed Effects
/
Asthma
/
Air Pollutants
/
Air Pollution
Type of study:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspects:
Determinantes_sociais_saude
Limits:
Child
/
Female
/
Humans
/
Infant
/
Male
/
Pregnancy
Language:
En
Journal:
Asian Pac J Allergy Immunol
Year:
2023
Document type:
Article
Country of publication:
TAILANDIA
/
TAILÂNDIA
/
TH
/
THAILAND