Breaking through the barrier: Modelling and exploiting the physical microenvironment to enhance drug transport and efficacy.

Gladysz, Magdalena Z; Stevanoska, Maja; Wlodarczyk-Biegun, Malgorzata K; Nagelkerke, Anika

Gladysz, Magdalena Z; Stevanoska, Maja; Wlodarczyk-Biegun, Malgorzata K; Nagelkerke, Anika.

Affiliation

Gladysz MZ; Pharmaceutical Analysis, Groningen Research Institute of Pharmacy, University of Groningen, P.O. Box 196, XB20, 9700 AD Groningen, the Netherlands; Polymer Science, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG, the Netherlands.
Stevanoska M; Pharmaceutical Analysis, Groningen Research Institute of Pharmacy, University of Groningen, P.O. Box 196, XB20, 9700 AD Groningen, the Netherlands.
Wlodarczyk-Biegun MK; Polymer Science, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG, the Netherlands; Biotechnology Centre, Silesian University of Technology, Krzywoustego 8, 44-100 Gliwice, Poland. Electronic address: malgorzata.wlodarczyk-biegun@polsl.pl.
Nagelkerke A; Pharmaceutical Analysis, Groningen Research Institute of Pharmacy, University of Groningen, P.O. Box 196, XB20, 9700 AD Groningen, the Netherlands. Electronic address: a.p.nagelkerke@rug.nl.

Adv Drug Deliv Rev ; 184: 114183, 2022 05.

Article in En | MEDLINE | ID: mdl-35278523

Subject(s)

Blood-Brain Barrier; Drug Delivery Systems; Biological Transport; Extracellular Matrix; Humans; Pharmaceutical Preparations

Key words

Blood-brain barrier; Extracellular matrix; In vitro models; Intestinal barrier; Mechanical properties

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood-Brain Barrier / Drug Delivery Systems Limits: Humans Language: En Journal: Adv Drug Deliv Rev Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2022 Document type: Article Affiliation country: Netherlands

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