The role of 18F-FDG PET/CT metabolic parameters in pediatric lymphoblastic lymphoma.
Rev Esp Med Nucl Imagen Mol (Engl Ed)
; 41(2): 91-99, 2022.
Article
in En
| MEDLINE
| ID: mdl-35292144
ABSTRACT
OBJECTIVE:
This retrospective study aimed to evaluate the role of metabolic parameters of 18F-FDG PET/CT in pediatric lymphoblastic lymphoma (LBL).METHODS:
Thirty patients with LBL underwent 42 scans. Metabolic parameters including maximum standardized uptake value (SUVmax), total metabolic tumor volume (TMTV), and total lesion glycolysis (TLG) were measured at baseline PET/CT. Univariate and multivariate analysis for survival were performed to assess their prognostic value. Twelve patients underwent PET/CT after reinduction regime, and the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of PET/CT for predicting relapse were calculated.RESULTS:
Patients with stage â £ had a higher TMTV than those with stage III (pâ¯=â¯0.031). Besides, patients with T-LBL or mediastinal involvement had a high TMTV and TLG (pâ¯<â¯0.05). There was no significant difference in PET/CT metabolic parameters between patients with different outcomes (pâ¯>â¯0.05). Children with a low TMTV (<242.91â¯cm³) had a better 3-year EFS compared with those with a high TMTV (88.9% vs. 56.3%; pâ¯=â¯0.036). SUVmax and TLG were not predictive of EFS (pâ¯=â¯0.874; pâ¯=â¯0.152). However, none of the metabolic parameters of baseline PET/CT were independent prognostic factors for outcomes of pediatric LBL. PET/CT underwent after reinduction regime present with higher sensitivity (50% vs. 0%) and NPV (90% vs. 83.3%) for predicting relapse than CT alone.CONCLUSIONS:
Metabolic parameters of baseline PET/CT were not predictive of outcomes in children with LBL. PET/CT done after the reinduction regime had better sensitivity and NPV than CT alone, and a negative scan could be a reliable indicator for sustained remission.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fluorodeoxyglucose F18
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Child
/
Humans
Language:
En
Journal:
Rev Esp Med Nucl Imagen Mol (Engl Ed)
Year:
2022
Document type:
Article
Affiliation country:
China