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Drug-like molecules with anti-trypanothione synthetase activity identified by high throughput screening.
Benítez, Diego; Franco, Jaime; Sardi, Florencia; Leyva, Alejandro; Durán, Rosario; Choi, Gahee; Yang, Gyongseon; Kim, Taehee; Kim, Namyoul; Heo, Jinyeong; Kim, Kideok; Lee, Honggun; Choi, Inhee; Radu, Constantin; Shum, David; No, Joo Hwan; Comini, Marcelo A.
Affiliation
  • Benítez D; Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay.
  • Franco J; Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay.
  • Sardi F; Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay.
  • Leyva A; Analytical Biochemistry and Proteomics Unit, Institut Pasteur de Montevideo, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.
  • Durán R; Analytical Biochemistry and Proteomics Unit, Institut Pasteur de Montevideo, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.
  • Choi G; Host-Parasite Research Laboratory, Institut Pasteur Korea, Gyeonggi-do, Republic of Korea.
  • Yang G; Host-Parasite Research Laboratory, Institut Pasteur Korea, Gyeonggi-do, Republic of Korea.
  • Kim T; Assay Development and Screening, Institut Pasteur Korea, Gyeonggi-do, Republic of Korea.
  • Kim N; Assay Development and Screening, Institut Pasteur Korea, Gyeonggi-do, Republic of Korea.
  • Heo J; Assay Development and Screening, Institut Pasteur Korea, Gyeonggi-do, Republic of Korea.
  • Kim K; Automation and Logistics Management, Institut Pasteur Korea, Gyeonggi-do, Republic of Korea.
  • Lee H; Automation and Logistics Management, Institut Pasteur Korea, Gyeonggi-do, Republic of Korea.
  • Choi I; Medicinal Chemistry, Institut Pasteur Korea, Gyeonggi-do, Republic of Korea.
  • Radu C; Automation and Logistics Management, Institut Pasteur Korea, Gyeonggi-do, Republic of Korea.
  • Shum D; Assay Development and Screening, Institut Pasteur Korea, Gyeonggi-do, Republic of Korea.
  • No JH; Host-Parasite Research Laboratory, Institut Pasteur Korea, Gyeonggi-do, Republic of Korea.
  • Comini MA; Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay.
J Enzyme Inhib Med Chem ; 37(1): 912-929, 2022 Dec.
Article in En | MEDLINE | ID: mdl-35306933
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanosoma cruzi / Leishmania infantum / Amide Synthases / Antineoplastic Agents / Antiprotozoal Agents Type of study: Diagnostic_studies / Screening_studies Limits: Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2022 Document type: Article Affiliation country: Uruguay Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trypanosoma cruzi / Leishmania infantum / Amide Synthases / Antineoplastic Agents / Antiprotozoal Agents Type of study: Diagnostic_studies / Screening_studies Limits: Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2022 Document type: Article Affiliation country: Uruguay Country of publication: United kingdom