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Design and synthesis of an N-benzyl 5-(4-sulfamoylbenzylidene-2-thioxothiazolidin-4-one scaffold as a novel NLRP3 inflammasome inhibitor.
Zuo, Dongxu; Do, Nayeon; Hwang, Inhwa; Ann, Jihyae; Yu, Je-Wook; Lee, Jeewoo.
Affiliation
  • Zuo D; Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
  • Do N; Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
  • Hwang I; Department of Microbiology and Immunology, BK 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
  • Ann J; Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: jihuya@snu.ac.kr.
  • Yu JW; Department of Microbiology and Immunology, BK 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Republic of Korea. Electronic address: jewookyu@yuhs.ac.
  • Lee J; Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: jeewoo@snu.ac.kr.
Bioorg Med Chem Lett ; 65: 128693, 2022 06 01.
Article in En | MEDLINE | ID: mdl-35314328
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2022 Document type: Article Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammasomes / NLR Family, Pyrin Domain-Containing 3 Protein Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2022 Document type: Article Country of publication: United kingdom