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Role of inflammation in pediatric irritable bowel syndrome.
Di Nardo, Giovanni; Cremon, Cesare; Staiano, Annamaria; Stanghellini, Vincenzo; Borrelli, Osvaldo; Strisciuglio, Caterina; Romano, Claudio; Mallardo, Saverio; Scarpato, Elena; Marasco, Giovanni; Salvatore, Silvia; Zenzeri, Letizia; Felici, Enrico; Pensabene, Licia; Sestito, Simona; Francavilla, Ruggiero; Quitadamo, Paolo; Baldassarre, Mariella; Giorgio, Valentina; Tambucci, Renato; Ziparo, Chiara; Parisi, Pasquale; Barbaro, Maria Raffaella; Barbara, Giovanni.
Affiliation
  • Di Nardo G; NESMOS Department, Faculty of Medicine and Psychology, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy.
  • Cremon C; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
  • Staiano A; Department of Translational Medical Science, "Federico II", University of Naples, Naples, Italy.
  • Stanghellini V; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
  • Borrelli O; Division of Neurogastroenterology and Motility, Department of Paediatric Gastroenterology, UCL Institute of Child Health and Great Ormond Street Hospital, London, UK.
  • Strisciuglio C; Department of Woman, Child and General and Specialistic Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
  • Romano C; Pediatric Gastroenterology Unit, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.
  • Mallardo S; Pediatric Department, Santa Maria Goretti Hospital, Sapienza University of Rome, Latina, Italy.
  • Scarpato E; Department of Translational Medical Science, "Federico II", University of Naples, Naples, Italy.
  • Marasco G; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
  • Salvatore S; Pediatric Department, Ospedale "F. Del Ponte", University of Insubria, Varese, Italy.
  • Zenzeri L; NESMOS Department, Faculty of Medicine and Psychology, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy.
  • Felici E; Pediatric Emergency Unit, Santobono-Pausilipon Children's Hospital, Naples, Italy.
  • Pensabene L; Pediatric and Pediatric Emergency Unit, "Umberto Bosio" Center for Digestive Diseases, The Children Hospital, AO SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
  • Sestito S; Department of Medical and Surgical Sciences, Pediatric Unit, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
  • Francavilla R; Department of Medical and Surgical Sciences, Pediatric Unit, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
  • Quitadamo P; Pediatric Section, Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy.
  • Baldassarre M; Department of Pediatrics, A.O.R.N. Santobono-Pausilipon, Naples, Italy.
  • Giorgio V; Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, University of Bari "Aldo Moro", Bari, Italy.
  • Tambucci R; Department of Pediatrics, Catholic University, Rome, Italy.
  • Ziparo C; Digestive Endoscopy and Surgery Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
  • Parisi P; NESMOS Department, Faculty of Medicine and Psychology, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy.
  • Barbaro MR; NESMOS Department, Faculty of Medicine and Psychology, Sant'Andrea University Hospital, Sapienza University of Rome, Rome, Italy.
  • Barbara G; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Neurogastroenterol Motil ; 35(3): e14365, 2023 03.
Article in En | MEDLINE | ID: mdl-35340083
ABSTRACT

BACKGROUND:

IBS affects a large number of children throughout the world and is thought to be the result of disturbed neuroimmune function along with the brain-gut axis. Although the underlying pathophysiologic mechanisms are not clear, the role of low-grade inflammation and mucosal immune activation in IBS symptom generation has become evident also in subsets of pediatric patients. Animal models provided meaningful insight in the causal relationship between abnormal mucosal immune activation and changes in gastrointestinal (GI) sensory-motor function. Likewise, the development of long-standing GI symptoms fulfilling the current criteria for functional GI disorders after infection gastroenteritis and in patients with IBD or celiac disease in remission further supports this hypothesis. Immune activation, its impact on gut sensory-motor function, and potential implications for symptom generation emerged in both children and adults with IBS.

PURPOSE:

The aim of this review is to summarize the main evidence on the presence of low-grade inflammation and immune activation in children with IBS, its possible role in symptom generation, and its potential implication for new therapeutic strategies.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Irritable Bowel Syndrome / Gastroenteritis Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neurogastroenterol Motil Journal subject: GASTROENTEROLOGIA / NEUROLOGIA Year: 2023 Document type: Article Affiliation country: Italy
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Irritable Bowel Syndrome / Gastroenteritis Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neurogastroenterol Motil Journal subject: GASTROENTEROLOGIA / NEUROLOGIA Year: 2023 Document type: Article Affiliation country: Italy