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Metabolism of a New Dipeptide Neuroprotector in Rats.
Kolyvanov, G B; Bochkov, P O; Litvin, A A; Shevchenko, R V; Podol'ko, A L; Kravtsova, O Yu; Kolyasnikova, K N; Zherdev, V P.
Affiliation
  • Kolyvanov GB; Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Bochkov PO; Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Litvin AA; Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. litbiopharm@yandex.ru.
  • Shevchenko RV; Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Podol'ko AL; Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Kravtsova OY; Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Kolyasnikova KN; Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
  • Zherdev VP; Laboratory of Pharmacokinetics, V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
Bull Exp Biol Med ; 172(5): 579-582, 2022 Mar.
Article in En | MEDLINE | ID: mdl-35352249
ABSTRACT
Metabolism of a new neuroprotector GZK-111 (N-phenylacetylglycyl-L-proline ethyl ester) in rat blood plasma was studied by HPLC-mass spectrometry. Four biotransformation products were identified. It is concluded that the main ways of GZK-111 biotransformation are hydrolysis of the ester bond by esterases followed by degradation of the resulting metabolite, as well as reactions leading to the formation of phenylacetic acid and cycloprolylglycine that exhibits neuropsychotropic activity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neuroprotective Agents / Dipeptides Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2022 Document type: Article Affiliation country: RUSSIA
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neuroprotective Agents / Dipeptides Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2022 Document type: Article Affiliation country: RUSSIA