Your browser doesn't support javascript.
loading
IFNγ Helps CBLB-Deficient CD8+ T Cells to Put Up Resistance to Tregs.
Wolf, Dominik; Baier, Gottfried.
Affiliation
  • Wolf D; Department of Internal Medicine V, Hematology and Oncology, Comprehensive Cancer Center Innsbruck (CCCI) and Tyrolean Cancer Research Institute (TKFI), Medical University of Innsbruck, Innsbruck, Austria.
  • Baier G; Institute of Cell Genetics, Department for Genetics, Medical University of Innsbruck, Innsbruck, Austria.
Cancer Immunol Res ; 10(4): 370, 2022 04 01.
Article in En | MEDLINE | ID: mdl-35362047
ABSTRACT
In this issue, Han and colleagues demonstrate in preclinical cancer models that genetic deletion of the E3 ubiquitin ligase Cbl proto-oncogene B (CBLB) in adoptively transferred CD8+ T cells induces resistance to regulatory T cells. CBLB deletion induces IFNγ and downmodulates TGFß/SMAD signaling. This ultimately enforces these cells to be way more effective against various cancers. See related article by Han et al., p. 437 (4).
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adaptor Proteins, Signal Transducing / Proto-Oncogene Proteins c-cbl Language: En Journal: Cancer Immunol Res Year: 2022 Document type: Article Affiliation country: Austria
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adaptor Proteins, Signal Transducing / Proto-Oncogene Proteins c-cbl Language: En Journal: Cancer Immunol Res Year: 2022 Document type: Article Affiliation country: Austria