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Bioactive Scalarane-Type Sesterterpenoids from Marine Sources.
Yu, Hao-Bing; Chen, Hai-Yan; Duan, Song; Zhu, Yu-Ping; Hu, Bo; He, Ying; Cheng, Si-Tong; Jiao, Bing-Hua; Liu, Xiao-Yu.
Affiliation
  • Yu HB; Department of Marine Biomedicine and Polar Medicine, Naval Medical Center of PLA, Naval Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.
  • Chen HY; Department of Endocrinology, Changzheng Hospital, Naval Medical University, Shanghai, 200003, P. R. China.
  • Duan S; Department of Marine Biomedicine and Polar Medicine, Naval Medical Center of PLA, Naval Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.
  • Zhu YP; College of Basic Medical Sciences, Experimental Teaching Center, Naval Medical University, Shanghai, 200433, China.
  • Hu B; Department of Marine Biomedicine and Polar Medicine, Naval Medical Center of PLA, Naval Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.
  • He Y; Department of Marine Biomedicine and Polar Medicine, Naval Medical Center of PLA, Naval Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.
  • Cheng ST; WLSA Shanghai Academy, Shanghai, 2004333, P. R. China.
  • Jiao BH; Department of Marine Biomedicine and Polar Medicine, Naval Medical Center of PLA, Naval Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.
  • Liu XY; Department of Marine Biomedicine and Polar Medicine, Naval Medical Center of PLA, Naval Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.
Chem Biodivers ; 19(5): e202200049, 2022 May.
Article in En | MEDLINE | ID: mdl-35393745
ABSTRACT
Scalarane-type sesterterpenoids have received considerable attention in the scientific literature due to their diverse carbon skeletons and various biological activities and pharmacological properties. Among all these derivatives are commonly isolated from marine sponges and are occasionally derived from shell-less mollusks, such as nudibranchs. This review comprehensively discusses the marine-derived natural sources that give rise to these scalarane-type sesterterpenoids, providing the names, their chemical structures, biological properties, with emphasis on anticancer activity and literature references related to these metabolites. A critical summary of the 221 compounds generated from January 2010 up to December 2021 for their potential as anticancer agents is presented.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Porifera / Biological Products / Antineoplastic Agents Limits: Animals Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2022 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Porifera / Biological Products / Antineoplastic Agents Limits: Animals Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2022 Document type: Article