Systematically mapping gray matter abnormal patterns in drug-naïve first-episode schizophrenia from childhood to adolescence.
Cereb Cortex
; 33(4): 1452-1461, 2023 02 07.
Article
in En
| MEDLINE
| ID: mdl-35396845
ABSTRACT
BACKGROUND:
Schizophrenia originates early in neurodevelopment, underscoring the need to elaborate on anomalies in the still maturing brain of early-onset schizophrenia (EOS).METHODS:
Gray matter (GM) volumes were evaluated in 94 antipsychotic-naïve first-episode EOS patients and 100 typically developing (TD) controls. The anatomical profiles of changing GM deficits in EOS were detected using 2-way analyses of variance with diagnosis and age as factors, and its timing was further charted using stage-specific group comparisons. Interregional relationships of GM alterations were established using structural covariance network analyses.RESULTS:
Antagonistic interaction results suggested dynamic GM abnormalities of the left fusiform gyrus, inferior occipital gyrus, and lingual gyrus in EOS. These regions comprise a dominating part of the ventral stream, a ventral occipitotemporal (vOT) network engaged in early social information processing. GM abnormalities were mainly located in the vOT regions in childhood-onset patients, whereas in the rostral prefrontal cortex (rPFC) in adolescent-onset patients. Moreover, compared with TD controls, patients' GM synchronization with the ventral stream was disrupted in widespread high-order social perception regions including the rPFC and salience network.CONCLUSIONS:
The current findings reveal age-related anatomical abnormalities of the social perception system in pediatric patients with schizophrenia.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Schizophrenia
Type of study:
Prognostic_studies
Limits:
Adolescent
/
Child
/
Humans
Language:
En
Journal:
Cereb Cortex
Journal subject:
CEREBRO
Year:
2023
Document type:
Article
Affiliation country:
China